Evidence mapPaperPMID 40125616Full record

ArticleCancer medicine2025

Disparities Between Rural and Urban Patients With Prostate Cancer in Nebraska.

Cassie Liu, Kaeli K Samson, Oleg Shats, Raymond Bergan

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Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cassie LiuEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0003-3907-9409
Kaeli K SamsonDepartment of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Oleg ShatsEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Raymond BerganEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joyce C Solheim · 1985 to 2026
$55.0M
Regulation of extracellular proteases in prostate cancer progression to a metastatic phenotypeR01CA276846 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BERGAN, RAYMOND C., NATARAJAN, AMARNATH (AMAR) · 2023 to 2025
$2.9M
NCI NIH HHS P30CA036727NIH HHS R01CA276846
6 · The paper itself

Abstract

introductionStudies focused on rural-urban disparities in patients with prostate cancer have demonstrated minimal differences in incidence and overall survival (OS). However, available data are limited, especially in understudied geographic locations. In this study, we investigated additional measures of potential cancer disparity and focused on examining rural-urban prostate cancer disparity in Nebraska residents.

methodsPatients diagnosed with prostate cancer from 1991 to 2023 living in Nebraska were identified in the integrated Cancer Repository for Cancer Research (iCaRe2) and categorized as rural and urban by rural-urban commuting area (RUCA) codes.

resultsResults are presented as mean ± standard deviation. The iCaRe2 patient registry contained data on 765 men with prostate cancer living in Nebraska, 621 (81.2%) of whom were urban residents and 144 (18.8%) of whom were rural residents. Rural residents were diagnosed with prostate cancer 3.1 years younger than urban residents (rural: 65.6 ± 8.21 years, urban: 68.7 ± 9.08 years, p < 0.001). Rural residents died of prostate cancer 4.2 years younger than urban residents (rural: 72.9 ± 9.75 years, urban: 77.1 ± 8.85 years, p < 0.001). Analyses of Gleason score and AJCC stage did not reveal statistically significant differences between rural and urban residents. OS was similar between rural and urban men in Nebraska with prostate cancer, congruent with currently published literature.

conclusionsOur analysis demonstrates that rural patients in Nebraska are diagnosed and die with prostate cancer at younger ages compared to urban patients. Our findings offer strategies to better define and delineate rural-urban cancer disparity and support future, more robust investigations to consider novel approaches to determining disparities in cancer disease course.

Indexed as

Healthcare DisparitiesHealth Status DisparitiesProstatic NeoplasmsRural PopulationUrban PopulationAgedAged, 80 and overHumansIncidenceMaleMiddle AgedNebraskaRegistriesage of deathage of diagnosiscancer disparityiCaRe2Nebraskaprostate cancerruralrural–urban disparityurban

Identifiers

PMID40125616
PMCPMC11931398

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.