Evidence map›Paper›PMID 40126368›Full record

ArticleJournal of proteome research2025

Large-Scale Quantitative Cross-Linking and Mass Spectrometry Provide New Insight into Protein Conformational Plasticity within Organelles, Cells, and Tissues.

Andrew Keller, Anna Bakhtina, James E Bruce

Abstract read
In one paragraph

Article in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. State-of-the-Art and Future Directions in Structural Proteomics.Molecular & cellular proteomics : MCP · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Andrew KellerDepartment of Genome Sciences, University of Washington, Seattle, Washington 98105, United States.
Anna BakhtinaDepartment of Genome Sciences, University of Washington, Seattle, Washington 98105, United States.ORCID 0000-0003-4550-1135
James E BruceDepartment of Genome Sciences, University of Washington, Seattle, Washington 98105, United States.ORCID 0000-0001-6441-6089

Funding

Dynamics of the cellular interactomeR35GM136255 · NIGMS · UNIVERSITY OF WASHINGTON · PI James Edward Bruce · 2020 to 2026
$4.0M
The heart failure interactomeR01HL144778 · NHLBI · UNIVERSITY OF WASHINGTON · PI BRUCE, JAMES EDWARD · 2019 to 2022
$2.7M
Aging Mitochondrial InteractomeR01AG078279 · NIA · UNIVERSITY OF WASHINGTON · PI James Edward Bruce, David J. Marcinek · 2023 to 2026
$2.2M
NHLBI NIH HHS R01 HL144778NIA NIH HHS R01 AG078279NIGMS NIH HHS R35 GM136255
6 · The paper itself

Abstract

Many proteins can exist in multiple conformational states

Indexed as

Cross-Linking ReagentsMass SpectrometryOrganellesProteinsAnimalsDatabases, ProteinHumansProtein ConformationProtein Processing, Post-TranslationalProteomicsCross-Linking ReagentsProteinschemical cross-linkingcross-link databasemass spectrometryprotein complexesprotein structuresquantitative XL-MS

Identifiers

PMID40126368
PMCPMC12767268

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.