Evidence map›Paper›PMID 40126602›Full record

ArticleSurgery today2025

Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath.

Akiisa Omura, Toru Kimura, Tomohiro Maniwa, Tadashi Watabe, Keiichiro Honma, Yasushi Shintani, Jiro Okami

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In one paragraph

Article in Surgery today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Akiisa OmuraDepartment of General Thoracic Surgery, Osaka International Cancer Institute, Osaka, Japan.
Toru KimuraDepartment of General Thoracic Surgery, Osaka International Cancer Institute, Osaka, Japan. kimura@thoracic.med.osaka-u.ac.jp.
Tomohiro ManiwaDepartment of General Thoracic Surgery, Osaka International Cancer Institute, Osaka, Japan.
Tadashi WatabeDepartment of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Japan.
Keiichiro HonmaDepartment of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, Osaka, Japan.
Yasushi ShintaniDepartment of General Thoracic Surgery, Osaka University Graduate School of Medicine, 2-2-L5, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Jiro OkamiDepartment of General Thoracic Surgery, Osaka International Cancer Institute, Osaka, Japan.

Funding

Japan Society for the Promotion of Science JP22K09014
6 · The paper itself

Abstract

purposeSolitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that can develop in the pleura. In the past, SFTs were considered benign, but there have been reports of SFTs being highly malignant. Fibroblast activation protein (FAP) is a serine protease, overexpressed in various cancers, which has been explored as a diagnostic and therapeutic target. We analyzed patients who underwent resection of an intrathoracic SFT, including metastatic pulmonary nodules from extrathoracic organs.

methodsThe subjects of this retrospective study were seven patients with a primary SFT and two with metastatic SFTs in the lungs. After immunohistochemical staining of the resected tumors, quantification of the stained area was performed using QuPath.

resultsImmunohistochemical quantification of FAP showed that it was expressed to varying degrees in the intrathoracic SFTs, with higher expression levels observed in metastatic SFTs than in primary pleural SFTs. Pathological examination confirmed the expression of FAP.

conclusionOur results support the potential usefulness of FAP in the diagnosis of intrathoracic SFTs, including metastatic pulmonary nodules.

Indexed as

Biomarkers, TumorGelatinasesImmunohistochemistryMembrane ProteinsSerine EndopeptidasesSolitary Fibrous TumorsThoracic NeoplasmsAdultAgedEndopeptidasesFemaleFibroblast Activation Protein AlphaHumansLung NeoplasmsMaleMiddle AgedBiomarkers, TumorEndopeptidasesFibroblast Activation Protein AlphaGelatinasesMembrane ProteinsSerine EndopeptidasesDiagnostic targetFibroblast activation proteinMalignant potentialPleural tumorSolitary fibrous tumor

Identifiers

PMID40126602
PMCPMC12380990

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.