Trial reportIndian pediatrics2025
Docosahexaenoic Acid Supplementation During Pregnancy and Lactation and Infant Morbidity: Findings from DHANI Trial.
Trial report in Indian pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the impact of maternal supplementation with docosahexaenoic acid (DHA) during pregnancy and lactation on the immune and inflammatory functions in infants and specific infant morbidities.
methodsA double-blinded, parallel-group, randomized, placebo-controlled trial was conducted among healthy pregnant women aged 18-35 years, from ≤ 20 weeks gestation through 6 months postpartum, to investigate the effectiveness of supplementation of 400 mg algal-derived DHA compared to placebo. Of 3379 women who were screened, 1171 were eligible, and 957 were randomized. Occurrences of 11 common morbidity symptoms including cough, nasal congestion, difficulty in breathing, cyanosis, convulsions, fever, vomiting, rash, ear discharge, excessive crying, and diarrhea were assessed for the offspring at 1, 6, and 12 months via maternal recall.
resultsOverall, there were 902 (out of 957) live births. Morbidity data were available for 871, 847, and 878 infants at 1, 6 and 12 months, respectively. The history of cough, difficulty in breathing, cyanosis, convulsions, fever, and vomiting at 1, 6, or 12 months were similar across DHA and placebo groups. At 1-month of age, fewer infants in the DHA group experienced any respiratory infection symptoms (cough, nasal congestion, and/or difficulty in breathing) as compared to placebo [29.3% vs 34.9%, P = 0.04; OR (95% CI) 0.74 (0.55, 0.98)]. At 6 months, there were fewer occurrences of 'other' symptoms like anemia, constipation, conjunctivitis, jaundice, and urinary tract infections in the DHA group [1.4% vs 4.8%, P = 0.005; OR (95% CI) 0.29 (0.11, 0.72)].
conclusionsPre- and postnatal maternal DHA supplementation did not show major differences in the incidence of common morbidity symptoms among infants at 1, 6, and 12 months. Meticulously planned and implemented studies on morbidity during infancy will be required to assess impact of maternal DHA supplementation on the morbidity during infancy.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.