Evidence map›Paper›PMID 40127573›Full record

ArticleVaccine2025

Effect of lymphocyte miRNA expression on influenza vaccine-induced immunity.

Iana H Haralambieva, Tamar Ratishvili, Krista M Goergen, Diane E Grill, Whitney L Simon, Jun Chen, Inna G Ovsyannikova, Gregory A Poland, Richard B Kennedy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Iana H HaralambievaMayo Clinic Vaccine Research Group, USA.
Tamar RatishviliMayo Clinic Vaccine Research Group, USA.
Krista M GoergenDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Diane E GrillDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Whitney L SimonMayo Clinic Vaccine Research Group, USA.
Jun ChenDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Inna G OvsyannikovaMayo Clinic Vaccine Research Group, USA.
Gregory A PolandMayo Clinic Vaccine Research Group, USA.
Richard B KennedyMayo Clinic Vaccine Research Group, USA. Electronic address: kennedy.rick@mayo.edu.

Funding

Bioinformatics Approach to Influenza A/H1N1 Vaccine Immune ProfilingU01AI089859 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2010 to 2015
$33.8M
Transcriptomic Signatures of Influenza Vaccine ResponsesR01AI132348 · NIAID · MAYO CLINIC ROCHESTER · PI KENNEDY, RICHARD B, POLAND, GREGORY A. · 2018 to 2022
$3.9M
NIAID NIH HHS R01 AI132348NIAID NIH HHS U01 AI089859
6 · The paper itself

Abstract

Alterations of gene expression by miRNAs contribute substantially to genetic regulation and cellular functions. We conducted a comprehensive study in 53 individuals before and after seasonal inactivated influenza vaccine to characterize lymphocyte-specific miRNA expression (in purified B cells, CD4+ T cells, CD8+ T cells, and NK cells) and its effect on influenza vaccine-induced immune outcomes (hemagglutination inhibition antibody titers/HAI, viral neutralizing antibody titers /VNA, and memory B cell ELISPOT). Overall, we observed relatively stable miRNA expression before and after influenza vaccination. Statistical analysis uncovered three baseline miRNAs (miR-150-3p, miR-629-5p, and miR-4443) that were significantly correlated with influenza vaccine-induced immune outcomes in different cell types. Predictive modeling of influenza vaccine-induced HAI/VNA titers identified a set of specific baseline miRNAs in CD4

Indexed as

Influenza, HumanInfluenza VaccinesLymphocytesMicroRNAsAdultAntibodies, NeutralizingAntibodies, ViralB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleHemagglutination Inhibition TestsHumansKiller Cells, NaturalMaleMiddle AgedAntibodies, NeutralizingAntibodies, ViralInfluenza VaccinesMicroRNAsVaccines, InactivatedB cellsImmunityInfluenza vaccineMicroRNA expressionNK cellsT cells

Identifiers

PMID40127573
PMCPMC12320940

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.