Evidence map›Paper›PMID 40127747›Full record

ArticleExperimental eye research2025

Effect of brimonidine on retinal ganglion cell function by in vivo calcium imaging of optic nerve crush in mice.

Tingting Li, Tia J Kowal, Jingyu Zhao, Liang Li, Qing Wang, Ke Ning, Chien-Hui Lo, Zhiquan Liu, Yingchun Shen, Jing Yu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tingting LiDepartment of Ophthalmology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94306, USA.
Tia J KowalDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94306, USA.
Jingyu ZhaoDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94306, USA.
Liang LiDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94306, USA.
Qing WangDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94306, USA.
Ke NingDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94306, USA.
Chien-Hui LoDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94306, USA.
Zhiquan LiuDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94306, USA.
Yingchun ShenDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94306, USA.
Jing YuDepartment of Ophthalmology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai 201399, China. Electronic address: dryujing@aliyun.com.
Haiying JinDepartment of Ophthalmology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China. Electronic address: eagle_jin@163.com.
Yang SunDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94306, USA; Palo Alto Veterans Administration, Palo Alto, CA, USA. Electronic address: yangsun@stanford.edu.

Funding

The role of primary cilia in glaucoma pathogenesisR01EY025295 · NEI · STANFORD UNIVERSITY · PI Yang Sun · 2016 to 2026
$3.5M
Phosphoinositide signaling in glaucoma: rescue strategies for Lowe syndromeR01EY032159 · NEI · STANFORD UNIVERSITY · PI SUN, YANG · 2021 to 2024
$1.6M
Glaucoma Pathogenesis of Oculocerebrorenal syndrome of LoweK08EY022058 · NEI · STANFORD UNIVERSITY · PI SUN, YANG · 2012 to 2016
$994k
Stanford Ophthalmology Advanced Research ProgramR38EY037090 · NEI · STANFORD UNIVERSITY · PI Yang Sun · 2025 to 2026
$495k
BLRD VA I01 BX006638CSRD VA I01 CX001481NEI NIH HHS K08 EY022058NEI NIH HHS R01 EY025295NEI NIH HHS R01 EY032159NEI NIH HHS R38 EY037090
6 · The paper itself

Abstract

Brimonidine has shown neuroprotective effects in animal studies, but clinical trials failed to demonstrate effective endpoints. Here, we used a newly developed in vivo calcium imaging method to measure RGC function of brimonidine in mice optic nerve crush (ONC) models. To transduce RGCs in vivo, wild-type C57Bl/6j mice were treated with intravitreal AAV2-mSncg-jGCaMP7s, a live-cell Ca

Indexed as

Adrenergic alpha-2 Receptor AgonistsBrimonidine TartrateCalciumOptic Nerve InjuriesRetinal Ganglion CellsAnimalsCalcium SignalingDisease Models, AnimalIntraocular PressureMiceMice, Inbred C57BLNerve CrushAdrenergic alpha-2 Receptor AgonistsBrimonidine TartrateCalciumBrimonidineCalcium imagingOptic nerve crushRetinal ganglion cell

Identifiers

PMID40127747
PMCPMC12058395

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.