SynthesisFuture oncology (London, England)2025
Systematic review on postoperative opioid use and other outcomes after lobectomy for lung cancer in the U.S.
Synthesis in Future oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of erector spinae block on postoperative outcomes in patients undergoing lung surgical procedures: a systematic review and trial sequential analysis of randomized controlled trials.BMC anesthesiology · 2026Pooled it
- Association between perioperative opioid consumption and postoperative outcomes in lung cancer surgery: evidence from a retrospective study with inflammatory and immune biomarker analysis.American journal of cancer research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis systematic review summarizes literature on postoperative opioid use in lung cancer patients after lobectomy, focusing on opioid consumption, survival, recurrence, pain scores, length of stay, readmission, and in-hospital mortality.
methodsPubMed and Embase were searched from 1 January 1993, to 31 May 2024, for observational studies on U.S. lung cancer patients. Retrospective studies reporting the outcomes of interest were included, excluding pediatric populations, non-English publications, non-lung cancer studies, reviews, meta-analyses, economic modeling papers, or interventional studies.
resultsOut of 683 identified articles, 22 studies met inclusion criteria, encompassing 77,315 patients. Commonly used opioids were morphine, hydromorphone, and fentanyl. Pain scores varied by surgical approach, with better control reported with video-assisted thoracoscopic surgery (VATS) and liposomal bupivacaine (LB). Longer hospital stays were linked to higher odds of persistent opioid use. Higher opioid doses were associated with decreased overall survival (OS) and recurrence-free survival.
conclusionsThe review highlights the complex relationship between postoperative opioid use and outcomes in lung cancer patients post-lobectomy. Alternatives like intercostal nerve blocks with LB and VATS can reduce opioid use and enhance recovery, emphasizing personalized pain management. Future research should focus on reducing opioid overprescription and patient education to minimize long-term use.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.