ArticleSchizophrenia (Heidelberg, Germany)2025
Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample.
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Article in Schizophrenia (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
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Who cites it
7 citing papers in PubMed.
- Processing Speed and Verbal Learning Ability as Predictors of Assessor-Rated and Ecological Momentary Assessment Self-Reported Functioning: Findings from AMP SCZ.Schizophrenia bulletin · 2026Article
- Overcoming Patient Access Barriers in Complex Conditions: Lessons from Schizophrenia for Broader Healthcare Applications.Journal of market access & health policy · 2026Article
- Body fluid biomarkers and psychosis risk in The Accelerating Medicines Partnership® Schizophrenia Program: design considerations.Schizophrenia (Heidelberg, Germany) · 2025Article
- Pathways to prevention: the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) Program.Schizophrenia (Heidelberg, Germany) · 2025Article
- Enabling FAIR data stewardship in complex international multi-site studies: Data Operations for the Accelerating Medicines Partnership® Schizophrenia Program.Schizophrenia (Heidelberg, Germany) · 2025Article
- Data analysis strategies for the Accelerating Medicines Partnership® Schizophrenia Program.Schizophrenia (Heidelberg, Germany) · 2025Article
- Baseline Clinical Characterization of Participants in the Accelerating Medicines Partnership Schizophrenia Program.Schizophrenia bulletin open · 2025Article
Corrections and comments
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Authors and funding
98 authors.
Kelly AllottOrygen, Parkville, VIC, Australia. kelly.allott@orygen.org.au.ORCID http://orcid.org/0000-0002-0640-4634
Walid YassinDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9612-0485
Luis AlamedaGeneral Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-8621-2885
Tashrif BillahDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Owen BordersDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kate BuccilliOrygen, Parkville, VIC, Australia.
Ricardo E CarriónDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine, Hempstead, NY, USA.ORCID http://orcid.org/0000-0002-6393-392X
Rolando I Castillo-PassiDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.ORCID http://orcid.org/0000-0002-9446-074X
Kang Ik K ChoDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7135-3848
Kota ChinDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Michael J ColemanDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Beau-Luke ColtonOrygen, Parkville, VIC, Australia.
Sebastián CorralDepartment of Psychiatry, University of Chile, Santiago, Chile.
Dominic DwyerOrygen, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0003-3949-5867
Kristina Ballestad GundersenVIRTU Research Group, Copenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-3277-4564
Ruben C GurDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Gil D HoftmanNorthwell Health, Glen Oaks, NY, USA.
Grace R JacobsDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9961-6507
Sinead KellyDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kathryn E LewandowskiPsychotic Disorders Division, McLean Hospital, Belmont, MA, USA.ORCID http://orcid.org/0000-0003-1477-6187
Patricia J MarcyNorthwell Health, Glen Oaks, NY, USA.
Priya MatnejaNorthwell Health, Glen Oaks, NY, USA.
Danielle McLaughlinNorthwell Health, Glen Oaks, NY, USA.
Angela R NunezDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Setari ParsaDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center and Harvard Medical School, Boston, MA, USA.
Nora PenzelDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1624-386X
Susan RayNorthwell Health, Glen Oaks, NY, USA.
Jenna M ReinenIBM Research, Armonk, NY, USA.
Kosha RuparelDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael S SandS2 Consulting LLC, Monroe, CT, USA.
Gennarina SantorelliDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center and Harvard Medical School, Boston, MA, USA.
Johanna Seitz-HollandDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1815-2681
Jessica SparkOrygen, Parkville, VIC, Australia.
Zailyn TamayoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Andrew ThompsonOrygen, Parkville, VIC, Australia.
Sophie TodOrygen, Parkville, VIC, Australia.
Cassandra M J WannanOrygen, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0003-1317-4635
Alana WickhamDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Stephen J WoodOrygen, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0003-4186-5919
Eirini ZoupouDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jean AddingtonDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0002-8298-0756
Alan AnticevicDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain.ORCID http://orcid.org/0000-0003-3382-4754
Nicholas J K BreitbordeDepartment of Psychiatry and Behavioral Health, Ohio State University, Columbus, OH, USA.
Matthew R BroomeInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-6963-8884
Kristin S CadenheadUniversity of California, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-5952-4605
Monica E CalkinsDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Eric Yu Hai ChenDepartment of Psychiatry, School of Clinical Medicine, LKF Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China.ORCID http://orcid.org/0000-0002-5247-3593
Jimmy ChoiOlin Neuropsychiatry Research Center, Hartford Health Care Behavioral Health Network, Hartford, CT, USA.
Philippe ConusGeneral Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Cheryl M CorcoranDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8902-4353
Barbara A CornblattDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine, Hempstead, NY, USA.
Lauren M EllmanDepartment of Psychology & Neuroscience, Temple University, Philadelphia, PA, USA.
Paolo Fusar-PoliDepartment of Psychosis Studies, King's College London, London, UK.
Pablo A GasparInstitute of Behavioral Science, Feinstein Institute for Medical Research, Manhasset, NY, USA.ORCID http://orcid.org/0000-0002-9682-5327
Carla GerberPrevention Science Institute, University of Oregon, Eugene, OR, USA.
Louise Birkedal GlenthøjVIRTU Research Group, Copenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen, Copenhagen, Denmark.
Leslie E HortonDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Christy Lai Ming HuiDepartment of Psychiatry, School of Clinical Medicine, LKF Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China.
Joseph KambeitzUniversity of Cologne, Faculty of Medicine and University HospitalCologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-8988-3959
Lana Kambeitz-IlankovicUniversity of Cologne, Faculty of Medicine and University HospitalCologne, Cologne, Germany.
Matcheri KeshavanDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center and Harvard Medical School, Boston, MA, USA.
Sung-Wan KimDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.ORCID http://orcid.org/0000-0002-6739-2163
Nikolaos KoutsoulerisDepartment of Psychosis Studies, King's College London, London, UK.ORCID http://orcid.org/0000-0001-6825-6262
Jun Soo KwonDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-1060-1462
Kerstin LangbeinDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Daniel MamahDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Covadonga M Diaz-CanejaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain.ORCID http://orcid.org/0000-0001-8538-3175
Daniel H MathalonDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6090-4974
Vijay A MittalDepartment of Psychology, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-9017-5119
Merete NordentoftCopenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen, Copenhagen, Denmark.
Godfrey D PearlsonOlin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-9396-2206
Jesus PerezCAMEO, Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
Albert R PowersConnecticut Mental Health Center, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-3057-5043
Jack RogersInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
Fred W SabbPrevention Science Institute, University of Oregon, Eugene, OR, USA.
Jason SchiffmanDepartment of Psychological Science, University of California, Irvine, CA, USA.
Jai L ShahPEPP-Montreal, Douglas Research Centre, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-7549-6990
Steven M SilversteinDepartment of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-0699-0960
Stefan SmesnyDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Gregory P StraussDepartment of Psychology, University of Georgia, Athens, GA, USA.
Judy L ThompsonDepartment of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.
Rachel UpthegroveInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0001-8204-5103
Swapna K VermaInstitute of Mental Health, Singapore, Singapore.
Jijun WangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-5427-7425
Daniel H WolfDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9731-8781
Ofer PasternakDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sylvain BouixDepartment of Software Engineering and Information Technology, Ecole de technologie superieure, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-1326-6054
Patrick D McGorryOrygen, Parkville, VIC, Australia.
John M KaneDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine, Hempstead, NY, USA.
Rene S KahnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5909-8004
Carrie E BeardenDepartments of Psychiatry and Biobehavioral Sciences & Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8516-923X
Martha E ShentonDepartments of Psychiatry and Radiology, Brigham and Women's Hospital, and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4235-7879
Scott W WoodsConnecticut Mental Health Center, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-3103-5228
Barnaby NelsonOrygen, Parkville, VIC, Australia.
Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ)
William S StoneDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center and Harvard Medical School, Boston, MA, USA.
Funding
ProNET: Psychosis-Risk Outcomes NetworkU01MH124639 · NIMH · YALE UNIVERSITY · PI CARRIE E BEARDEN, JOHN M KANE · 2020 to 2026
$81.2MPsychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination CenterU24MH124629 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI Rene S. Kahn, Martha E. Shenton · 2020 to 2026
$32.6MTrajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT)U01MH124631 · NIMH · UNIVERSITY OF MELBOURNE · PI Christopher Barnaby Nelson · 2020 to 2026
$30.4MNIMH NIH HHS U01 MH124631NIMH NIH HHS U01 MH124639NIMH NIH HHS U24 MH124629U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) U01MH124631U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) U01MH124639U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) U24MH124629Wellcome TrustWellcome Trust (Wellcome) 220664/A/20/ZWellcome Trust (Wellcome) 220664/Z/20/Z
Abstract
Cognitive impairment occurs at higher rates in individuals at clinical high risk (CHR) for psychosis relative to healthy peers, and it contributes unique variance to multivariate prediction models of transition to psychosis. Such impairment is considered a core biomarker of schizophrenia. Thus, cognition is a key domain measured in the Accelerating Medicines Partnership® program for Schizophrenia (AMP SCZ initiative). The aim of this paper is to describe the rationale, processes, considerations, and final harmonization of the cognitive battery used in AMP SCZ across the two data collection networks. This battery comprises tests of general intellect and specific cognitive domains. We estimate premorbid intelligence at baseline and measure current intelligence at baseline and 2 years. Eight tests from the Penn Computerized Neurocognitive Battery (PennCNB), which measure verbal learning and memory, sensorimotor ability, attention, emotion recognition, working memory, processing speed, verbal memory, visual memory, and motor speed are administered repeatedly at baseline, and four follow-up timepoints over 2 years.
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