Evidence map›Paper›PMID 40128351›Full record

ArticleScientific reports2025

A stable NTN1 fluorescent reporter chicken reveals cell specific molecular signatures during optic fissure closure.

Brian Ho Ching Chan, Holly Hardy, Teresa Requena, Amy Findlay, Jason Ioannidis, Dominique Meunier, Maria Toms, Mariya Moosajee, Anna Raper, Mike J McGrew and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brian Ho Ching Chan *The Division of Functional Genetics, The Roslin Institute, Midlothian, EH25 9RG, UK.
Holly Hardy *The Division of Functional Genetics, The Roslin Institute, Midlothian, EH25 9RG, UK.
Teresa Requena *The Division of Functional Genetics, The Roslin Institute, Midlothian, EH25 9RG, UK.
Amy FindlayThe Division of Functional Genetics, The Roslin Institute, Midlothian, EH25 9RG, UK.
Jason IoannidisThe Division of Functional Genetics, The Roslin Institute, Midlothian, EH25 9RG, UK.
Dominique MeunierThe Division of Functional Genetics, The Roslin Institute, Midlothian, EH25 9RG, UK.
Maria TomsUCL Institute of Ophthalmology, London, EC1V 9EL, UK.
Mariya MoosajeeUCL Institute of Ophthalmology, London, EC1V 9EL, UK.
Anna RaperThe Division of Functional Genetics, The Roslin Institute, Midlothian, EH25 9RG, UK.
Mike J McGrewThe Division of Functional Genetics, The Roslin Institute, Midlothian, EH25 9RG, UK.
Joe RaingerThe Division of Functional Genetics, The Roslin Institute, Midlothian, EH25 9RG, UK. joe.rainger@roslin.ed.ac.uk.ORCID http://orcid.org/0000-0003-1091-5100

Funding

Biotechnology and Biological Sciences Research Council BBS/E/D/10002071UKRI Future Leaders Fellowship MR/S033165/1
6 · The paper itself

Abstract

NTN1 is expressed in a wide range of developmental tissues and is essential for normal development. Here we describe the generation of a Netrin-1 reporter chicken line (NTN1-T2A-eGFP) by targeting green fluorescent protein into the NTN1 locus using CRISPR/Cas9 methodology. Our strategy gave 100% transmission of heterozygous (NTN1

Indexed as

EyeNetrin-1AnimalsChick EmbryoChickensColobomaCRISPR-Cas SystemsGene Expression Regulation, DevelopmentalGenes, ReporterGreen Fluorescent Proteinsenhanced green fluorescent proteinGreen Fluorescent ProteinsNetrin-1

Identifiers

PMID40128351
PMCPMC11933247

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.