Evidence map›Paper›PMID 40128648›Full record

ArticleBMC medical imaging2025

The correlation analysis between Normalized Wall Index and cerebral perfusion in patients with Mild Carotid Artery Stenosis under 3.0T MRI.

Yonggang Cai, Shouming Chen, Tongyu Shang, Binze Han, Lei Zhang, Changyan Xu, Zhibin He, Ting Yin

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Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yonggang CaiImaging Center, Affiliated Hospital of Panzhihua University, No. 27, Taoyuan Street, East District, Panzhihua City, Sichuan Province, China.
Shouming ChenImaging Center, Affiliated Hospital of Panzhihua University, No. 27, Taoyuan Street, East District, Panzhihua City, Sichuan Province, China. chenshouming2024@yeah.net.
Tongyu ShangImaging Center, Affiliated Hospital of Panzhihua University, No. 27, Taoyuan Street, East District, Panzhihua City, Sichuan Province, China.
Binze HanImaging Center, Affiliated Hospital of Panzhihua University, No. 27, Taoyuan Street, East District, Panzhihua City, Sichuan Province, China.
Lei ZhangImaging Center, Affiliated Hospital of Panzhihua University, No. 27, Taoyuan Street, East District, Panzhihua City, Sichuan Province, China.
Changyan XuImaging Center, Affiliated Hospital of Panzhihua University, No. 27, Taoyuan Street, East District, Panzhihua City, Sichuan Province, China.
Zhibin HeImaging Center, Affiliated Hospital of Panzhihua University, No. 27, Taoyuan Street, East District, Panzhihua City, Sichuan Province, China.
Ting YinImaging Center, Affiliated Hospital of Panzhihua University, No. 27, Taoyuan Street, East District, Panzhihua City, Sichuan Province, China.

Funding

Sichuan Medical Association (Hengrui) Research Fund 2021HR61
6 · The paper itself

Abstract

backgroundTo explore the relationship between Normalized Wall Index (NWI) and Magnetic Resonance Perfusion Imaging Parameters in Patients with Mild Carotid Artery Stenosis.

methodsInitially, an analysis was conducted on 40 patients from our institution, and we identified through ultrasonographic examinations conducted between July 2021 and August 2022. These patients exhibited carotid artery plaques with mild luminal narrowing (with stenosis rates ranging from 20 to 50%, following the criteria of the North American Symptomatic Carotid Endarterectomy Trial, NASCET). All cases underwent high-resolution magnetic resonance imaging (MRI) of the carotid arteries and cerebral perfusion assessments using 3.0T MRI during the specified timeframe. Based on whether the cerebral hemisphere in the carotid artery supply region had experienced ischemic events, including Transient Ischemic Attacks (TIAs), patients were categorized into symptomatic and asymptomatic groups. Subsequently, the Normalized Wall Index (NWI) of the carotid arteries and the area of abnormal perfusion on the same side of the brain were calculated for each group.

resultsIn the symptomatic group, all patients exhibited perfusion abnormalities in the internal carotid artery supply region, whereas only some patients in the asymptomatic group showed such abnormalities. The NWI of plaques in the symptomatic group was significantly higher than that in the asymptomatic group (P < 0.05).

conclusionThe range of prolongation in mean transit time (MTT) and time to peak (TTP) in patients with perfusion abnormalities was positively correlated with NWI and stenosis rates. The association with NWI was more pronounced and statistically significant (P < 0.05).

Indexed as

Carotid StenosisCerebrovascular CirculationMagnetic Resonance ImagingAgedAged, 80 and overFemaleHumansMaleMiddle AgedCarotid artery plaquesCerebral perfusionCerebrovascular eventsHigh-resolution magnetic resonance vessel wall imagingLuminal narrowingNormalized wall index

Identifiers

PMID40128648
PMCPMC11934482

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.