Evidence map›Paper›PMID 40128702›Full record

ArticleBMC nephrology2025

Mercury poisoning-associated membranous nephropathy and autoimmune encephalitis.

Caihong Liu, Yongxiu Huang, Wei Wei, Xinyu Hu, Jing Yang, Yuliang Zhao

Abstract readCase Reports
In one paragraph

Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Acrodynia and CASPR2 Autoimmunity in Elemental Mercury Toxicity.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Caihong LiuDepartment of Nephrology, Institute of Kidney Diseases, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, Sichuan Province, 610041, China.
Yongxiu HuangDepartment of Nephrology, Institute of Kidney Diseases, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, Sichuan Province, 610041, China.
Wei WeiDepartment of Nephrology, Institute of Kidney Diseases, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, Sichuan Province, 610041, China.
Xinyu HuDepartment of Pathology, West China Hospital, Sichuan University, Chengdu, China.
Jing YangDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yuliang ZhaoDepartment of Nephrology, Institute of Kidney Diseases, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, Sichuan Province, 610041, China. zhaoyuliang@scu.edu.cn.

Funding

135 Project for Disciplines of Excellence, West China Hospital, Sichuan University 2020HXFH014
6 · The paper itself

Abstract

Mercury intoxication is not uncommon and often presents with diverse symptoms of multiple systems. While neurological disorders and renal impairments have been examined in isolation, the concurrent occurrence of systemic symptoms linked to immune dysregulation is infrequently observed. Here, we report an unusual case that a 55-year-old male patient, who is a scrap merchant, was admitted to our center for neuropsychiatric disturbances, including incoherent speech and hallucinations. He was initially diagnosed with autoimmune encephalitis (AE) because of double positivity for CASPR2 and LGl1 antibodies in serum. The patient later presented with pruritus and nephrotic syndrome, where renal biopsy revealed membranous nephropathy (MN). In view of the mercury exposure history and elevated urinary mercury level, AE and MN were suspected to be related to mercury poisoning. The patient achieved a full recovery following a four-month treatment regimen comprising immunosuppressants and mercury-chelating agents, underscoring the significance of recognizing environmental toxins such as mercury in the coexisting diseases of different systems such as AE and MN.

Indexed as

EncephalitisGlomerulonephritis, MembranousHashimoto DiseaseMercury PoisoningHumansImmunosuppressive AgentsMaleMiddle AgedImmunosuppressive AgentsAutoimmune encephalitisCase reportMembranous nephropathyMercury poisoning

Identifiers

PMID40128702
PMCPMC11934491

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.