ArticleEuropean journal of medical research2025
Uncovering the subtle relationship between vitamin D and kidney stones: a cross-sectional NHANES-based study.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Association of the TyG-related indices with hypertension-diabetes comorbidity in middle-aged and older adults: a suburban community-based study.BMC cardiovascular disorders · 2026Article
- BMI mediates the association between red cell distribution width to serum albumin index and kidney stone risk: a population-based study.Therapeutic advances in urologyArticle
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Abstract
objectiveThis study investigated the potential correlation between serum vitamin D levels and the risk of kidney stones. To this end, the National Health and Nutrition Examination Survey (NHANES) database resources from 2007 to 2018 were utilized. The influence of other demographic characteristics, lifestyle habits, and chronic diseases on this relationship was also assessed.
methodsThis study included 59,842 participants from the NHANES survey, and after exclusions, 24,323 individuals with complete data were analyzed. Logistic regression modeling assessed odds ratios (OR) and 95% confidence intervals (CI) between vitamin D levels and kidney stone risk, and multivariable adjustment models were constructed to control for potential confounders. To investigate the dose-response relationship between vitamin D and kidney stones, restricted cubic spline (RCS) modeling was employed. Subgroup and interaction analyses were also conducted.
resultsThe preliminary analyses indicated a statistically significant positive correlation between vitamin D levels and kidney stone risk before adjustment for potential confounding variables (OR = 1.01, P < 0.001). However, after gradual adjustment for age, gender, race, and multiple lifestyle and chronic diseases, this association became non-significant (OR = 1.00, P = 0.186). Furthermore, RCS analyses demonstrated that the non-linear relationship between vitamin D levels and kidney stone risk was no longer statistically significant after adjustment for confounders. In the subgroup analyses, only slight statistical associations were observed in the subgroups of vigorous exercise and those with diabetes, with no significant differences in the remaining subgroups.
conclusionThe present study indicates that serum vitamin D level is not an independent predictor of kidney stone risk. Rather, its effect may be co-regulated by multiple confounding factors. Further research is required to elucidate the precise mechanisms through which vitamin D contributes to kidney stone formation and to consider the combined effects of genetic polymorphisms, dose effects, and other factors.
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