Evidence map›Paper›PMID 40128912›Full record

ArticleMicrobiome2025

Dietary emulsifier carboxymethylcellulose-induced gut dysbiosis and SCFA reduction aggravate acute pancreatitis through classical monocyte activation.

Yongpu Feng, Wenjin Chen, Jiayu Chen, Fengyuan Sun, Fanyang Kong, Lei Li, Yating Zhao, Shouxin Wu, Zhaoshen Li, Yiqi Du and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yongpu Feng *National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, China.
Wenjin Chen *Department of Urology, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200092, China.
Jiayu Chen *Changhai Clinical Research Unit, Naval Medical University, Shanghai, 200433, People's Republic of China.
Fengyuan Sun *National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, China.
Fanyang Kong *National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, China.
Lei Li *Digestive Endoscopy Center, Shanghai Tenth People'S Hospital, Tongji University School of Medicine, Shanghai, 200433, China.
Yating ZhaoNational Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, China.
Shouxin WuShanghai Zhenwei Biotechnology Co., Ltd, Shanghai, 200245, China.
Zhaoshen LiChanghai Clinical Research Unit, Naval Medical University, Shanghai, 200433, People's Republic of China. zhsl@vip.163.com.
Yiqi DuShanghai Institute of Pancreatic Diseases, Shanghai, 200433, China. duyiqi@hotmail.com.
Xiangyu KongNational Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, China. xiangyukong185@hotmail.com.

Funding

National Key R&D Program of China 2019YFC1315900National Natural Science Foundation of China 82072760National Natural Science Foundation of China 82170659National Natural Science Foundation of China 82172572
6 · The paper itself

Abstract

objectiveCarboxymethylcellulose (CMC), one of the most common emulsifiers used in the food industry, has been reported to promote chronic inflammatory diseases, but its impact on acute inflammatory diseases, e.g., acute pancreatitis (AP), remains unclear. This study investigates the detrimental effects of CMC on AP and the potential for mitigation through Akkermansia muciniphila or butyrate supplementation.

designC57BL/6 mice were given pure water or CMC solution (1%) for 4 weeks and then subjected to caerulein-induced AP. The pancreas, colon, and blood were sampled for molecular and immune parameters associated with AP severity. Gut microbiota composition was assessed using 16S rRNA gene amplicon sequencing. Fecal microbiota transplantation (FMT) was used to illustrate gut microbiota's role in mediating the effects of CMC on host mice. Additional investigations included single-cell RNA sequencing, monocytes-specific C/EBPδ knockdown, LPS blocking, fecal short-chain fatty acids (SCFAs) quantification, and Akkermansia muciniphila or butyrate supplementation. Finally, the gut microbiota of AP patients with different severity was analyzed.

resultsCMC exacerbated AP with gut dysbiosis. FMT from CMC-fed mice transferred such adverse effects to recipient mice, while single-cell analysis showed an increase in classical monocytes in blood. LPS-stimulated C/EBPδ, caused by an impaired gut barrier, drives monocytes towards classical phenotype. LPS antagonist (eritoran), Akkermansia muciniphila or butyrate supplementation ameliorates CMC-induced AP exacerbation. Fecal Akkermansia muciniphila abundance was negatively correlated with AP severity in patients.

conclusionsThis study reveals the detrimental impact of CMC on AP due to gut dysbiosis, with Akkermansia muciniphila or butyrate offering potential therapeutic avenues for counteracting CMC-induced AP exacerbation. Video Abstract.

Indexed as

Carboxymethylcellulose SodiumDysbiosisFatty Acids, VolatileGastrointestinal MicrobiomeMonocytesPancreatitisAkkermansiaAnimalsButyratesDisease Models, AnimalFecal Microbiota TransplantationFecesHumansMaleMiceMice, Inbred C57BLButyratesCarboxymethylcellulose SodiumFatty Acids, VolatileRNA, Ribosomal, 16S

Identifiers

PMID40128912
PMCPMC11931840

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.