Evidence mapPaperPMID 40128964Full record

ArticleEndocrine journal2025

Severe obesity with hypo-leptinemia.

Masanori Kita, Shuhei Morita, Hiroyuki Ariyasu, Tomoya Tsuji, Shinsuke Uraki, Ken Takeshima, Hiroshi Iwakura, Taka-Aki Matsuoka

Abstract readCase Reports
In one paragraph

Article in Endocrine journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Masanori KitaFirst Department of Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.
Shuhei MoritaFirst Department of Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.ORCID http://orcid.org/0000-0002-4415-3805
Hiroyuki AriyasuDepartment of Diabetes and Endocrinology, Shizuoka General Hospital, Shizuoka 420-8527, Japan.ORCID http://orcid.org/0000-0002-9307-1275
Tomoya TsujiFirst Department of Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.
Shinsuke UrakiFirst Department of Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.
Ken TakeshimaFirst Department of Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.
Hiroshi IwakuraDepartment of Pharmacotherapeutics, School of Pharmaceutical Science, Wakayama Medical University, Wakayama 641-8509, Japan.
Taka-Aki MatsuokaFirst Department of Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some cases of obesity are thought to be associated with hypo-leptinemia. This may cause decreased appetite suppression resulting in increased appetite, leading to weight gain. Replacement therapy with leptin might be theoretically useful, but verification by reporting more cases is required. Here, we first investigated the serum leptin levels and their correlation with body mass index (BMI) in 107 patients with obesity to identify the subjects with hypo-leptinemia. Among them, one patient with congenital hypopituitarism was further investigated by comparison of his clinical and pathological characteristics with those of control subjects. This 40-year-old Japanese man, who was large from birth, consistently showed obesity of more than 2SD during his growth period. He had 41.5 kg/m

Indexed as

LeptinObesity, MorbidAdultBody Mass IndexFatal OutcomeHumansHypopituitarismMaleMiddle AgedLeptinHypopituitarismHypothalamic disordersLeptinObesity

Identifiers

PMID40128964
PMCPMC12260190

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.