Evidence map›Paper›PMID 40129172›Full record

ArticleMolecular biology and evolution2025

Road to Extinction? Past and Present Population Structure and Genomic Diversity in the Koala.

Binia De Cahsan, Marcela Sandoval Velasco, Michael V Westbury, David A Duchêne, Mikkel H Strander Sinding, Hernán E Morales, Daniela C Kalthoff, Ian Barnes, Selina Brace, Roberto Portela Miguez and 5 more

Abstract read
In one paragraph

Article in Molecular biology and evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Binia De CahsanGlobe Institute, University of Copenhagen, 1350 Copenhagen K, Denmark.ORCID 0000-0002-6978-6633
Marcela Sandoval VelascoGlobe Institute, University of Copenhagen, 1350 Copenhagen K, Denmark.ORCID 0000-0002-4635-6171
Michael V WestburyGlobe Institute, University of Copenhagen, 1350 Copenhagen K, Denmark.ORCID 0000-0003-0478-3930
David A DuchêneGlobe Institute, University of Copenhagen, 1350 Copenhagen K, Denmark.ORCID 0000-0002-5479-1974
Mikkel H Strander SindingDepartment of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.ORCID 0000-0003-1371-219X
Hernán E MoralesGlobe Institute, University of Copenhagen, 1350 Copenhagen K, Denmark.ORCID 0000-0002-2964-020X
Daniela C KalthoffDepartment of Zoology, Swedish Museum of Natural History, SE-104 05 Stockholm, Sweden.ORCID 0000-0003-2439-5484
Ian BarnesDepartment of Earth Sciences, Natural History Museum, London SW7 5BD, England, UK.ORCID 0000-0001-8322-6918
Selina BraceDepartment of Earth Sciences, Natural History Museum, London SW7 5BD, England, UK.ORCID 0000-0003-2126-6732
Roberto Portela MiguezDepartment of Life Sciences, Natural History Museum, London SW7 5BD, England, UK.ORCID 0000-0003-3094-9949
Alfred L RocaDepartment of Animal Sciences, University of Illinois, Urbana, IL 61801, USA.ORCID 0000-0001-9217-5593
Alex D GreenwoodDepartment of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, 10315 Berlin, Germany.ORCID 0000-0002-8249-1565
Rebecca N JohnsonSmithsonian National Museum of Natural History, Washington, D.C. 20560, USA.ORCID 0000-0003-3035-2827
Matthew J LottAustralian Centre for Wildlife Genomics, Australian Museum, Sydney, NSW 2010, Australia.ORCID 0000-0001-8685-8099
M Thomas P GilbertGlobe Institute, University of Copenhagen, 1350 Copenhagen K, Denmark.ORCID 0000-0002-5805-7195

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Koalas are arboreal herbivorous marsupials, endemic to Australia. During the late 1800s and early 1900s, the number of koalas declined dramatically due to hunting for their furs. In addition, anthropogenic activities have further decimated their available habitat, and decreased population numbers. Here, we utilize 37 historic and 25 modern genomes sampled from across their historic and present geographic range, to gain insights into how their population structure and genetic diversity have changed across time; assess the genetic consequences of the period of intense hunting, and the current genetic status of this iconic Australian species. Our analyses reveal how genome-wide heterozygosity has decreased through time and unveil previously uncharacterized mitochondrial haplotypes and nuclear genotypes in the historic dataset, which are absent from today's koala populations.

Indexed as

Extinction, BiologicalGenetic VariationPhascolarctidaeAnimalsAustraliaGenetics, PopulationGenomeHaplotypesancient DNAconservation genomicsKoalaspopulation genomics

Identifiers

PMID40129172
PMCPMC12014528

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.