Evidence map›Paper›PMID 40129569›Full record

ReviewFrontiers in cell and developmental biology2025

Mesenchymal stem cell-derived exosomes as a plausible immunomodulatory therapeutic tool for inflammatory diseases.

Muhammad Zubair, Fatma A Abouelnazar, Muhammad Asad Iqbal, Jingyun Pan, Xuwen Zheng, Tao Chen, Wenming Shen, Jinnan Yin, Yongmin Yan, Pengjun Liu and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Muhammad ZubairDepartment of Laboratory Medicine, Wujin Hospital Affiliated with Jiangsu University, Changzhou, China.
Fatma A AbouelnazarDepartment of Laboratory Medicine, Wujin Hospital Affiliated with Jiangsu University, Changzhou, China.
Muhammad Asad IqbalSchool of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Jingyun PanDepartment of Traditional Chinese Medicine, Wujin Hospital Affiliated with Jiangsu University, Changzhou, China.
Xuwen ZhengDepartment of Emergency, Wujin Hospital Affiliated With Jiangsu University, Changzhou, China.
Tao ChenDepartment of Gastroenterology, Wujin Hospital Affiliated With Jiangsu University, Changzhou, China.
Wenming ShenDepartment of Emergency, Wujin Hospital Affiliated With Jiangsu University, Changzhou, China.
Jinnan YinDepartment of Emergency, Wujin Hospital Affiliated With Jiangsu University, Changzhou, China.
Yongmin YanDepartment of Laboratory Medicine, Wujin Hospital Affiliated with Jiangsu University, Changzhou, China.
Pengjun LiuDepartment of Gastroenterology, Wujin Hospital Affiliated With Jiangsu University, Changzhou, China.
Fei MaoKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Ying ChuWujin Clinical College, Xuzhou Medical University, Changzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), especially, exosomes are considered to have diverse therapeutic effects for various significant diseases. MSC-derived exosomes (MSCex) offer substantial advantages over MSCs due to their long-term preservation, stability, absence of nuclei and fewer adverse effects such as infusion toxicity, thereby paving the way towards regenerative medicine and cell-free therapeutics. These exosomes harbor several cellular contents such as DNA, RNA, lipids, metabolites, and proteins, facilitating drug delivery and intercellular communication. MSCex have the ability to immunomodulate and trigger the anti-inflammatory process hence, playing a key role in alleviating inflammation and enhancing tissue regeneration. In this review, we addressed the anti-inflammatory effects of MSCex and the underlying immunomodulatory pathways. Moreover, we discussed the recent updates on MSCex in treating specific inflammatory diseases, including arthritis, inflammatory bowel disease, inflammatory eye diseases, and respiratory diseases such as asthma and acute respiratory distress syndrome (ARDS), as well as neurodegenerative and cardiac diseases. Finally, we highlighted the challenges in using MSCex as the successful therapeutic tool and discussed future perspectives.

Indexed as

exosomesimmunomodulationinflammatory diseasesmesenchymal stem cellstherapeutics

Identifiers

PMID40129569
PMCPMC11931156

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.