Evidence map›Paper›PMID 40130407›Full record

ReviewJournal of cell science2025

Fibronectin matrix assembly at a glance.

Yu Sun, Aaron J Hamlin, Jean E Schwarzbauer

Abstract readReview
In one paragraph

Review in Journal of cell science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Exosomes are specialized vehicles to induce fibronectin assembly.bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. CD8Frontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yu SunDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-0877-7186
Aaron J HamlinDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Jean E SchwarzbauerDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0003-1012-7593

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Fibronectin-dependent mechanisms governing the assembly of a definitive extracellular matrixR01AR073236 · NIAMS · PRINCETON UNIVERSITY · PI SCHWARZBAUER, JEAN E · 2018 to 2022
$1.7M
New Jersey Commission on Cancer Research COCR25PDF001NIAMS NIH HHS R01 AR073236NIGMS NIH HHS T32 GM007388NIH HHS R01 AR073236Sud Cook '39 Fund for the Prevention of Addiction to Alcohol and other Mind-altering Drugs
6 · The paper itself

Abstract

The organization and mechanics of extracellular matrix (ECM) protein polymers determine tissue structure and function. Secreted ECM components are assembled into polymers via a cell-mediated process. The specific mechanisms that cells use for assembly are crucial for generating tissue-appropriate matrices. Fibronectin (FN) is a ubiquitous and abundant ECM protein that is assembled into a fibrillar matrix by a receptor-mediated process, and the FN matrix provides a foundation for incorporation of many other proteins into the ECM. In this Cell Science at a Glance article and the accompanying poster, we describe the domain organization of FN and the events that initiate and propagate a stable insoluble network of FN fibrils. We also discuss intracellular pathways that regulate FN assembly and the impact of changes in assembly on disease progression.

Indexed as

Extracellular MatrixFibronectinsAnimalsHumansFibronectinsAssemblyExtracellular matrixFibrillogenesisFibronectin

Identifiers

PMID40130407
PMCPMC12050093

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.