ArticleEuropean journal of neurology2025
Peripheral Nerve Involvement in Friedreich's Ataxia Characterized by Quantitative Magnetic Resonance Neurography.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundFriedreich's ataxia (FRDA) affects both the central and peripheral nervous system. Peripheral nerve involvement manifests predominantly as a progressive sensory neuropathy caused by dorsal root ganglionopathy. An additional direct involvement of peripheral nerves leading to abnormal myelination is increasingly discussed. Here, we characterize lower extremity peripheral nerve involvement in FRDA by quantitative magnetic resonance neurography (MRN).
methodsSixteen genetically confirmed FRDA patients and 16 age-/sex-matched controls were prospectively enrolled. Patients underwent neurologic examinations and nerve conduction studies (NCS). Large-coverage MRN of sciatic and tibial nerves was conducted utilizing dual-echo turbo-spin-echo sequences with spectral fat saturation for T2-relaxometry, and two gradient-echo sequences with and without off-resonance saturation rapid frequency pulses for magnetization transfer contrast imaging. Microstructural and morphometric MRN markers including T2-relaxation time (T2
resultsTibial nerve ρ and T2
conclusionOur study results provide a profound characterization of peripheral nerve involvement in FRDA. The identified good correlation between ρ and T2
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