Evidence map›Paper›PMID 40130612›Full record

ArticleOrganic & biomolecular chemistry2025

A β-hairpin peptide derived from Aβ forms different oligomers in the crystal state and in aqueous solution.

Jason Zhu, Adam G Kreutzer, Zhiwei Liu, Xingyue Li, Sabrina M Richter, Vojislava Pophristic, James S Nowick

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic & biomolecular chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jason ZhuDepartment of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA. jsnowick@uci.edu.ORCID 0000-0002-5154-6092
Adam G KreutzerDepartment of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA. jsnowick@uci.edu.
Zhiwei LiuDepartment of Chemistry and Biochemistry, Rowan University, Glassboro, New Jersey 08028-1701, USA.
Xingyue LiDepartment of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA. jsnowick@uci.edu.
Sabrina M RichterDepartment of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA. jsnowick@uci.edu.ORCID 0009-0009-3066-3685
Vojislava PophristicDepartment of Chemistry and Biochemistry, Rowan University, Glassboro, New Jersey 08028-1701, USA.
James S NowickDepartment of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA. jsnowick@uci.edu.ORCID 0000-0002-2273-1029

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
Structural and Biological Characterization of Diverse Oligomers Derived from AbetaRF1AG072587 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 2021 to 2021
$1.4M
Structural and Biological Characterization of Diverse Oligomers Derived from AbetaR01AG072587 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 2024 to 2025
$994k
NIA NIH HHS R01 AG072587NIA NIH HHS RF1 AG072587NIGMS NIH HHS P30 GM124169
6 · The paper itself

Abstract

The supramolecular assembly of amyloid-β into soluble oligomers is critical Alzheimer's disease (AD) progression. Soluble Aβ oligomers have emerged as neurotoxic species involved in AD progression and some Aβ oligomers are thought to be composed of β-hairpins. In this work, we report the X-ray crystallographic and solution-phase assembly of a macrocyclic β-hairpin peptide that mimics a β-hairpin formed by Aβ

Indexed as

Amyloid beta-PeptidesCrystallography, X-RayModels, MolecularMolecular Dynamics SimulationSolutionsWaterAmyloid beta-PeptidesSolutionsWater

Identifiers

PMID40130612
PMCPMC12003087

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.