Evidence map›Paper›PMID 40130675›Full record

Trial reportRespirology (Carlton, Vic.)2025

Fixed CPAP at 10 cmH

Lu Wang, Yan Chen, Qishan Wei, Yingxin Wu, Cuizhen Huang, Shanfeng Liang, Joerg Steier, Peter Catcheside, Danny Eckert, Andrew Wellman and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Respirology (Carlton, Vic.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04925466 (Comparison of 10cmH2O and Manual Titrated Pressure in Treatment of Obstructive Sleep Apnea), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04925466 nacompletednot on this map

Comparison of 10cmH2O and Manual Titrated Pressure in Treatment of Obstructive Sleep Apnea(OSA) Patients

TypeinterventionalSponsorState Key Laboratory of Respiratory DiseaseRan2021 to 2021Enrolled40ConditionsObstructive Sleep Apnea of AdultArmsCPAP at pressure of 10 cmH2O, CPAP at minimal effective pressure
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Fixed CPAP at 10 cmHRespirology (Carlton, Vic.) · 2025
    Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Lu WangState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.ORCID 0009-0009-3736-9454
Yan ChenState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Qishan WeiState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Yingxin WuState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Cuizhen HuangState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Shanfeng LiangState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Joerg SteierGuy's & St Thomas' NHS Foundation Trust and King's College London, London, UK.
Peter CatchesideAISH, Flinders University, Adelaide, Australia.
Danny EckertAISH, Flinders University, Adelaide, Australia.
Andrew WellmanDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Yuanming LuoState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.

Funding

China Postdoctoral Science Foundation 2020M682677Guangzhou Municipal Health Commission Major Technical Project Grant 2023C-GX02National Natural Science Foundation of China 82070090
6 · The paper itself

Abstract

BACKGROUND AND

objectivesPatient compliance with continuous positive airway pressure (CPAP) is similar using manual-titrated pressure compared to auto-titration, although auto-titration pressures are usually 2-5 cmH

methodsPart 1, 12 healthy subjects and 16 OSA patients were enrolled in the measurement of expiratory reserve volume, diaphragm EMG, and expiratory muscle EMG at different CPAP levels. Breathing difficulty during different CPAP levels was assessed using a customised questionnaire in 35 healthy subjects and 33 OSA patients. Part 2, a two-night randomised crossover double-blind trial using the tolerable highest CPAP (10 cmH

resultsEnd expiratory lung volume increased significantly with increasing CPAP. In general, diaphragm EMG changed little when CPAP ≤ 10 cmH

conclusionsThis study suggests that most patients with moderate to severe OSA can be effectively treated with CPAP at an initial pressure of 10 cmH

trial registrationClinicalTrials.gov identifier: NCT04925466.

Indexed as

Continuous Positive Airway PressureSleep Apnea, ObstructiveAdultAgedCross-Over StudiesDiaphragmDouble-Blind MethodElectromyographyFemaleHumansMaleMiddle AgedPatient ComplianceSeverity of Illness Indexcontinuous positive airway pressureobstructive sleep apnoeatitration

Identifiers

PMID40130675
PMCPMC12321691

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.