Evidence map›Paper›PMID 40131856›Full record

ArticleBiochemistry2025

Genome-Wide Analysis of Stable RNA Secondary Structures across Multiple Organisms Using Chemical Probing Data: Insights into Short Structural Motifs and RNA-Targeting Therapeutics.

Jingxin Wang

Abstract read
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Jingxin WangSection of Genetic Medicine, Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0002-9414-4093

Funding

Modulating gene expression by RNA-targeting chimerasR35GM147498 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Jingxin Wang · 2022 to 2026
$2.1M
NIGMS NIH HHS R35 GM147498
6 · The paper itself

Abstract

Small molecules targeting specific RNA-binding sites, including stable and transient RNA structures, are emerging as effective pharmacological approaches for modulating gene expression. However, little is understood about how stable RNA secondary structures are shared across organisms, which is an important factor in controlling drug selectivity. In this study, I provide an analytical pipeline named RNA secondary structure finder (R2S-Finder) to discover short, stable RNA structural motifs in humans,

Indexed as

Nucleic Acid ConformationRNA, BacterialRNA, Viral5' Untranslated RegionsEscherichia coliHumansNucleotide MotifsSARS-CoV-2Zika Virus5' Untranslated RegionsRNA, BacterialRNA, Viral

Identifiers

PMID40131856
PMCPMC12005188

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.