Evidence map›Paper›PMID 40132446›Full record

ArticleEpilepsy & behavior : E&B2025

MK-212 precipitates seizure-induced death in amygdala-kindled mice via a non-5-HT

Katelyn G Joyal, Nicole A Boodhoo, Gordon F Buchanan

Abstract read
In one paragraph

Article in Epilepsy & behavior : E&B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Katelyn G JoyalInterdisciplinary Graduate Program in Neuroscience, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States; Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States.
Nicole A BoodhooDepartment of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States; Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States; Department of Biomedical Sciences, University of Iowa, Iowa City, IA 52242, United States.
Gordon F BuchananInterdisciplinary Graduate Program in Neuroscience, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States; Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States. Electronic address: gordon-buchanan@uiowa.edu.

Funding

Serotonergic circuit mechanisms in postictal recovery and arousalR01NS129722 · NINDS · UNIVERSITY OF IOWA · PI Gordon F Buchanan · 2023 to 2026
$2.4M
Sleep state-dependent mechanisms of seizure-induced deathR01NS095842 · NINDS · UNIVERSITY OF IOWA · PI BUCHANAN, GORDON F · 2016 to 2020
$2.1M
The effect of epilepsy and seizures on dorsal raphe serotonin neuron activity and arousalF31NS125955 · NINDS · UNIVERSITY OF IOWA · PI JOYAL, KATELYN · 2022 to 2023
$66k
NINDS NIH HHS F31 NS125955NINDS NIH HHS R01 NS095842NINDS NIH HHS R01 NS129722
6 · The paper itself

Abstract

Epilepsy is a common neurological condition that affects over 65 million people worldwide. Despite an increasing number of anti-seizure medications being made available, many patients do not find seizure freedom with medication. The leading cause of death in this refractory population is sudden unexpected death in epilepsy (SUDEP). Both human and animal research has implicated serotonin (5-HT) in modulating seizure proclivity, severity, and mortality. More recently, evidence has pointed to the 5-HT

Indexed as

AmygdalaKindling, NeurologicReceptor, Serotonin, 5-HT2CSeizuresSerotonin 5-HT2 Receptor AgonistsAnimalsDisease Models, AnimalDose-Response Relationship, DrugMaleMiceMice, Inbred C57BLReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor AgonistsKindlingSerotoninSUDEP

Identifiers

PMID40132446
PMCPMC12034472

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.