ArticleCell2025
Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force.
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Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
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Who cites it
30 citing papers in PubMed.
- The role of gut microbiota in chronic intestinal pseudo-obstruction: exploring fecal microbiota transplantation as a treatment option.Gut microbes · 2026Article
- Maladaptive Piezo1 Mechanotransduction Drives Smooth Muscle Aging in the Gut.bioRxiv : the preprint server for biology · 2026Article
- Piezo1 in digestive homeostasis and disease: Barrier function, immune signalling, cellular injury and metabolism.Clinical and translational medicine · 2026Review
- Piezo ion channels in the digestive system: Mechanotransduction pathways and therapeutic targeting strategies.Genes & diseases · 2026Review
- Desynchronization of intestinal circadian clocks and gastrointestinal dysfunction.Nature reviews. Gastroenterology & hepatology · 2026Article
- Piezo1 channel: structure, mechanogating mechanism, functions, diseases and therapeutic strategy.Molecular biomedicine · 2026Review
- Amifostine alleviates ionizing radiation-induced small intestinal motility dysfunction in mice by remodeling the structure of the enteric nervous system.Histochemistry and cell biology · 2026Article
- Vagus nerve stimulation limits colonic inflammation through distinct neuroimmune circuitry shaped by inflammatory history.bioRxiv : the preprint server for biology · 2026Article
- Linking Genetic Risk to Disease-Relevant Cellular States via Metacell-Informed Modeling with ICePop.bioRxiv : the preprint server for biology · 2026Article
- Review
- Neuro-immune interactions in gastrointestinal oncology: Mechanisms, challenges, and therapeutic potential.Innovation (Cambridge (Mass.)) · 2026Review
- Citrus aurantium honey-mediated gut homeostasis and anti-inflammation via Thorl/Nprl2-TORC1 signaling: Network pharmacology and Drosophila validation.Animal models and experimental medicine · 2026Article
- Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Characterizing Infiltrating Macrophages in Intracranial Aneurysm with IA Animal Models and Spatial Transcriptomics.Translational stroke research · 2026Review
- The Neuroimmune Connectome: Understanding how the Peripheral Nervous System shapes Immunity.ImmunoHorizons · 2026Review
- The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibitor.Apoptosis : an international journal on programmed cell death · 2026Review
- Enteric nervous system in exercise physiology: a microbiota-neural interface.npj metabolic health and disease · 2026Review
- Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging.Nature immunology · 2026Article
- YAP1 converts circELP2-mediated biochemical signals to mechanical forces through promoting cytoskeleton remodeling in pulmonary fibrosis.International journal of biological sciences · 2026Article
- Mechanosensitive ion channels in intestinal homeostasis and disease.eGastroenterology · 2026Review
Corrections and comments
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Authors and funding
32 authors.
Zili XieDepartment of Dermatology, The Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA; Department of Anesthesiology, The Center for the Study of Itch & Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.
Lillian RoseDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Jing FengDepartment of Anesthesiology, The Center for the Study of Itch & Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA; Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Science, University of Chinese Academy of Sciences, Beijing, China.
Yonghui ZhaoDepartment of Anesthesiology, The Center for the Study of Itch & Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.
Yisi LuDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Harry KaneDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Timothy J HibberdVisceral Neurophysiology Laboratory, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.
Xueming HuDepartment of Dermatology, The Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA; Department of Anesthesiology, The Center for the Study of Itch & Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.
Zhen WangDepartment of Dermatology, The Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA.
Kaikai ZangDepartment of Anesthesiology, The Center for the Study of Itch & Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.
Xingliang YangDepartment of Dermatology, The Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA; Department of Anesthesiology, The Center for the Study of Itch & Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.
Quentin RichardsonDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Rahmeh OthmanDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Olivia VeneziaDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Ademi ZhakypDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Fang GaoDepartment of Dermatology, The Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA; Department of Anesthesiology, The Center for the Study of Itch & Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA.
Nobuya AbeDepartment of Dermatology, The Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA.
Keren VigelandDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Hongshen WangDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Camren BranchDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Coco DuizerDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Liwen DengDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Xia MengDepartment of Dermatology, The Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA.
Lydia ZamidarDepartment of Dermatology, The Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA.
Max HauptscheinDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Ronan BerginKathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland.
Xinzhong DongThe Solomon H. Snyder Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Issac M ChiuDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Brian S KimDepartment of Dermatology, The Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Allen Discovery Center for Neuroimmune Interactions, New York, NY 10029, USA.
Nick J SpencerVisceral Neurophysiology Laboratory, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.
Hongzhen HuDepartment of Dermatology, The Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA; Department of Anesthesiology, The Center for the Study of Itch & Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63130, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Allen Discovery Center for Neuroimmune Interactions, New York, NY 10029, USA; The Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: hongzhen.hu@mssm.edu.
Ruaidhrí JacksonDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: ruaidhri_jackson@hms.harvard.edu.
Funding
Neuroimmune Regulation of Atopic DermatitisR01AR070116 · NIAMS · WASHINGTON UNIVERSITY · PI KIM, BRIAN · 2016 to 2021
$3.8MTARGETING THE TRANSIENT RECEPTOR POTENTIAL CHANNELS TO IMPROVE BOWEL DYSFUNCTIONR01DK103901 · NIDDK · WASHINGTON UNIVERSITY · PI HU, HONGZHEN · 2015 to 2023
$3.4MRegulation of IgE and Atopic ItchR01AI167933 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CONROY, MICHELLE E, KIM, BRIAN · 2022 to 2025
$3.2MDeciphering the Piezo2-Merkel cell signaling mechanisms in itchR01AR077183 · NIAMS · WASHINGTON UNIVERSITY · PI HU, HONGZHEN · 2020 to 2024
$2.6MIlluminating the immune system's genomic dark matter: functionally annotating the hidden translatomeDP2AI169979 · NIAID · HARVARD MEDICAL SCHOOL · PI JACKSON, RUAIDHRI · 2021 to 2024
$2.5MMECHANISMS OF TRPV4-MEDIATED NEUROPATHIC PAINR01AA027065 · NIAAA · WASHINGTON UNIVERSITY · PI HU, HONGZHEN · 2018 to 2022
$2.5MNatural Killer Cell Regulation of Skin InflammationR01AR077007 · NIAMS · WASHINGTON UNIVERSITY · PI KIM, BRIAN · 2021 to 2025
$2.5MGenetic Analysis of Intrinsic Sensory Neuron Function in the Enteric Neural CircuitsR01DK134773 · NIDDK · WASHINGTON UNIVERSITY · PI Hongzhen Hu · 2023 to 2026
$2.3MMolecular and cellular mechanisms of visceral pain and cross-organ sensitizationR01DK141106 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Hongzhen Hu, Brian Kim · 2024 to 2026
$2.2MDeveloping an Objective and Quantifiable Measure of Itch Using Artificial Intelligence and Radio SignalsR01AR080392 · NIAMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KATABI, DINA · 2022 to 2024
$642kThe Role of IL-33 in Chronic ItchR21AI167047 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KIM, BRIAN · 2021 to 2022
$460kNIAAA NIH HHS R01 AA027065NIAID NIH HHS DP2 AI169979NIAID NIH HHS R01 AI167933NIAID NIH HHS R21 AI167047NIAMS NIH HHS R01 AR070116NIAMS NIH HHS R01 AR077007NIAMS NIH HHS R01 AR077183NIAMS NIH HHS R01 AR080392NIDDK NIH HHS R01 DK103901NIDDK NIH HHS R01 DK134773NIDDK NIH HHS R01 DK141106
Abstract
The gastrointestinal (GI) tract experiences a myriad of mechanical forces while orchestrating digestion and barrier immunity. A central conductor of these processes, the enteric nervous system (ENS), detects luminal pressure to regulate peristalsis independently of extrinsic input from the central and peripheral nervous systems. However, how the ∼500 million enteric neurons that reside in the GI tract sense and respond to force remains unknown. Herein, we establish that the mechanosensor Piezo1 is functionally expressed in cholinergic enteric neurons. Optogenetic stimulation of Piezo1
Indexed as
Enteric Nervous SystemHomeostasisIon ChannelsAnimalsCholinergic NeuronsColitisColonFemaleGastrointestinal MotilityMaleMechanotransduction, CellularMiceMice, Inbred C57BLNeuronsOptogeneticsPeristalsisIon ChannelsPiezo1 protein, mousecholinergic neuronsenteric nervous systeminflammationinflammatory bowel diseasemechanosensationmotilityneuro-immuneperistalsisPiezo1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.