Evidence map›Paper›PMID 40132596›Full record

ArticleACS applied materials & interfaces2025

Ultrashort Peptides as Stabilizing Agents for Colloidal Nanogold.

Juan David Figueroa, Sergio D Garcia Schejtman, Ryan Tu, Marcelo Muñoz, Francisca Salas-Sepúlveda, Horacio Poblete, Marc-André Langlois, Erik J Suuronen, Emilio I Alarcón

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Juan David FigueroaBioengineering and Therapeutic Solutions (BEaTS) program, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y4W7, Canada.
Sergio D Garcia SchejtmanBioengineering and Therapeutic Solutions (BEaTS) program, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y4W7, Canada.
Ryan TuBioengineering and Therapeutic Solutions (BEaTS) program, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y4W7, Canada.ORCID 0009-0005-5538-8393
Marcelo MuñozBioengineering and Therapeutic Solutions (BEaTS) program, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y4W7, Canada.ORCID 0000-0001-7748-4996
Francisca Salas-SepúlvedaDepartamento de Bioinformática, Centro de Bioinformática, Simulación y Modelado (CBSM), Facultad de Ingeniería, Universidad de Talca, Campus Talca, 2 Norte 685, Talca 75710, Chile.
Horacio PobleteDepartamento de Bioinformática, Centro de Bioinformática, Simulación y Modelado (CBSM), Facultad de Ingeniería, Universidad de Talca, Campus Talca, 2 Norte 685, Talca 75710, Chile.ORCID 0000-0003-2650-3565
Marc-André LangloisDepartment of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Erik J SuuronenBioengineering and Therapeutic Solutions (BEaTS) program, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y4W7, Canada.
Emilio I AlarcónBioengineering and Therapeutic Solutions (BEaTS) program, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y4W7, Canada.ORCID 0000-0001-5100-6179

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultrashort peptides hold immense potential as structural tools for enhancing the colloidal stability of nanomaterials, such as nanogold. However, such applications have been largely unexplored in part due to the inherent complexity in designing, synthesizing, and testing short peptides as colloidal nanoparticle stabilizers. In this work, we use a motif-function-guided process for peptide synthesis and high throughput screening to evaluate the colloidal stability of spherical nanogold solutions and pentapeptides. We have successfully built a library of peptides capable of stabilizing colloidal nanogold at peptide concentrations of ≤1.0 μM. This represents a 50-100-fold reduction in the concentration required for stability compared to other small molecules used as capping agents, which illustrates the potential of using short peptide sequences as colloidal nanogold stabilizers. Our findings could significantly impact the future development of high-affinity surface modifiers for the custom engineering of nanogold by providing a deeper understanding of the complex interactions between nanoparticles and peptides.

Indexed as

GoldMetal NanoparticlesPeptidesColloidsColloidsGoldPeptidesnanogoldpeptide designpeptide structuresurface modificationultrashort peptides

Identifiers

PMID40132596
PMCPMC11988133

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.