Evidence map›Paper›PMID 40133016›Full record

ArticleMolecular pharmacology2025

Identification and molecular characterization of missense mutations in orphan G protein-coupled receptor GPR61 occurring in severe obesity.

Choi Har Tsang, Alexander De Rosa, Paweł Kozielewicz

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In one paragraph

Article in Molecular pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Choi Har TsangMolecular Pharmacology of GPCRs, Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden.
Alexander De RosaMolecular Pharmacology of GPCRs, Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden; School of Engineering Sciences (SCI), KTH Royal Institute of Technology, Stockholm, Sweden.
Paweł KozielewiczMolecular Pharmacology of GPCRs, Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden. Electronic address: pawel.kozielewicz@ki.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe obesity is a complex chronic metabolic condition with a body mass index over 40 and can be caused, for example, by dysregulated G protein-coupled receptors (GPCRs) signaling. The orphan GPCR GPR61 had been linked to the regulation of metabolism and, here, we identify 34 mutations in the GPR61 gene which are present with much higher frequency in severe obesity samples from the UK10K obesity screen compared to the normal population. Furthermore, the cumulative sum of GPR61 mutations was found to be higher compared to the highly mutated and well-established target, melanocortin 4 receptor. Some GPR61 mutations presented an impact on ligand-independent GPR61-induced cAMP production. Specifically, R236C

Indexed as

Mutation, MissenseObesity, MorbidReceptors, G-Protein-CoupledAdultAnimalsFemaleHEK293 CellsHumansMaleReceptor, Melanocortin, Type 4Receptor, Melanocortin, Type 4Receptors, G-Protein-CoupledBioluminescence resonance energy transferGPR61G protein–coupled receptorsMetabolismMissense mutationsOrphan receptorsSevere obesity

Identifiers

PMID40133016
PMCPMC12060159

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.