Evidence map›Paper›PMID 40133119›Full record

ReviewTrends in parasitology2025

Decoding arthropod vector immunology through bona fide pathogens.

Alejandra Wu-Chuang, Hanna J Laukaitis-Yousey, Matthew Butnaru, Stephanie E Mohr, Norbert Perrimon, Joao H F Pedra

Abstract readReview
In one paragraph

Review in Trends in parasitology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alejandra Wu-ChuangDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
Hanna J Laukaitis-YouseyDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
Matthew ButnaruDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Stephanie E MohrDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Joao H F PedraDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: jpedra@som.umaryland.edu.

Funding

Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Erol Fikrig, UTPAL PAL · 2018 to 2026
$13.5M
Ubiquitylation and Rickettsial Colonization of a Tick VectorR01AI116523 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2016 to 2025
$6.2M
Tick Saliva and Pathogen TransmissionR01AI134696 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Joao Pedra · 2018 to 2026
$5.1M
Rickettsial Immunity During Tick TransmissionR01AI093653 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2011 to 2015
$1.8M
Systems-Level Research in Microbial PathogenesisT32AI162579 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI NICHOLAS H CARBONETTI, Julie Dunning Hotopp · 2022 to 2026
$1.7M
Characterization of innate immune signaling pathways in the tick Ixodes scapularisR01AI186279 · NIAID · HARVARD MEDICAL SCHOOL · PI STEPHANIE E MOHR, NORBERT PERRIMON · 2025 to 2026
$1.6M
Establishing CRISPR cell screening for the deer tick Ixodes scapularis, a vector of Lyme and other diseasesR21AI168592 · NIAID · HARVARD MEDICAL SCHOOL · PI MOHR, STEPHANIE E, PEDRA, JOAO · 2022 to 2023
$469k
NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI093653NIAID NIH HHS R01 AI116523NIAID NIH HHS R01 AI134696NIAID NIH HHS R01 AI186279NIAID NIH HHS R21 AI168592NIAID NIH HHS T32 AI162579
6 · The paper itself

Abstract

The interrelationship between the microbiota, metabolism, and the arthropod immune system has evolved to maintain physiological equilibrium. Arthropods rely on this delicate balance when encountering fitness challenges. The understanding of life history traits in arthropod vectors has been hampered by technological difficulties compounded by limited scientific knowledge compared to established model organisms. Here, we posit that using emerging technologies to study environmental pathogens that cause greater fitness disadvantages to disease vectors (i.e., bona fide pathogens) in contrast to coevolved microbes will enable meaningful insights into arthropod immunophysiology. We propose a conceptual framework whereby understanding immunophysiology through the lens of bona fide pathogens, as opposed to coevolved microbes, should be useful for the management of vector-borne illnesses.

Indexed as

ArthropodsArthropod VectorsHost-Pathogen InteractionsAnimalsarthropod vectorsbona fide pathogenscoevolved microbesimmune systemmetabolism

Identifiers

PMID40133119
PMCPMC12064392

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.