SynthesisNature communications2025
Missense variants in FRS3 affect body mass index in populations of diverse ancestries.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Genetic variability in the leptin-melanocortin pathway and its role in weight loss.Molecular metabolism · 2026Review
- Leveraging the shared and opposing genetic mechanisms in the heritable cardiomyopathies.Research square · 2026Article
- Identifying pleiotropic genes for backfat thickness and semen traits in pigs using GWAS summary data.Journal of animal science · 2026Article
- Genome-Wide Association Study for Weight-Related Traits inAnimals : an open access journal from MDPI · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
76 authors.
Andrea B Jonsdottir *deCODE genetics/Amgen Inc., Reykjavik, Iceland. andrea.jonsdottir@decode.is.ORCID http://orcid.org/0009-0007-5252-098X
Gardar Sveinbjornsson *deCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-2429-9468
Rosa B ThorolfsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-7475-0398
Max TamlanderInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-2249-0971
Vinicius TragantedeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-8223-8957
Thorhildur OlafsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-2003-9984
Solvi RognvaldssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Asgeir SigurdssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Hannes P EggertssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-1674-9978
Hildur M AegisdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
David O ArnardeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Karina BanasikThe Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Doruk BeyterdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Ragnar G BjarnasonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Gyda BjornsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-8100-0306
Søren BrunakThe Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0316-5866
Mie Topholm BruunDepartment of Clinical Immunology, Odense University Hospital, Odense, Denmark.ORCID http://orcid.org/0000-0002-8819-5388
Joseph DowsettDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5381-2633
Eythor EinarssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0009-0008-5814-6981
Gudmundur EinarssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-1326-2339
Christian ErikstrupDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-6551-6647
Run FridriksdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Jonas GhouseDepartment of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Solveig GretarsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-2616-7269
Gisli H HalldorssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-7067-9862
Torben HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8748-3831
Anna HelgadottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-1806-2467
Peter C HolmThe Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Erna V IvarsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-2069-0681
Kasper Karmark IversenDepartment of Cardiology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Copenhagen, Denmark.
Bitten Aagaard JensenDepartment of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark.ORCID http://orcid.org/0000-0001-8306-1332
Ingileif JonsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-8339-150X
Stacey KnightIntermountain Medical Center, Intermountain Heart Institute, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0003-0092-7327
Kirk U KnowltonIntermountain Medical Center, Intermountain Heart Institute, Salt Lake City, UT, USA.
Snaedis KristmundsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-8981-0883
Adalheidur E LarusdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Olafur Th MagnussondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Gisli MassondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Pall MelsteddeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Christina MikkelsenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-2945-6197
Kristjan H S MooredeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-9579-4362
Asmundur OddssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-4606-5163
Pall I OlasondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Frosti PalssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Ole Birger PedersenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2312-5976
Michael SchwinnDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6151-369X
Emil L SigurdssonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Aron SkaftasondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Lilja StefansdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Hreinn StefanssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-9331-6666
Thora SteingrimsdottirFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Arni SturlusondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Unnur StyrkarsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-8146-8278
Erik SørensenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5002-9077
Unnur D TeitsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Thorgeir E ThorgeirssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Gudmundur A ThorissondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Unnur ThorsteinsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Magnus O UlfarssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Henrik UllumStatens Serum Institut, Copenhagen, Denmark.
Arnor VikingssonDepartment of Medicine, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.
G Bragi WaltersdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5415-6487
DBDS Genomic Consortium
Lincoln D NadauldPrecision Genomics, Intermountain Healthcare, Saint George, UT, USA.
Henning BundgaardDepartment of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Sisse Rye OstrowskiDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5288-3851
Agnar HelgasondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Bjarni V HalldorssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-0756-0767
Gudmundur L NorddahldeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Samuli RipattiInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-0504-1202
Daniel F GudbjartssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5222-9857
Gudmar ThorleifssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Valgerdur SteinthorsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-1846-6274
Hilma HolmdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Patrick SulemdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-7123-6123
Kari StefanssondeCODE genetics/Amgen Inc., Reykjavik, Iceland. kstefans@decode.is.ORCID http://orcid.org/0000-0003-1676-864X
Funding
Wellcome Trust
Abstract
Obesity is associated with adverse effects on health and quality of life. Improved understanding of its underlying pathophysiology is essential for developing counteractive measures. To search for sequence variants with large effects on BMI, we perform a multi-ancestry meta-analysis of 13 genome-wide association studies on BMI, including data derived from 1,534,555 individuals of European ancestry, 339,657 of Asian ancestry, and 130,968 of African ancestry. We identify an intergenic 262,760 base pair deletion at the MC4R locus that associates with 4.11 kg/m
Indexed as
Adaptor Proteins, Signal TransducingBody Mass IndexMutation, MissenseObesityAllelesAsian PeopleBlack PeopleBrain-Derived Neurotrophic FactorFemaleFinlandGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideReceptor, Melanocortin, Type 4White PeopleAdaptor Proteins, Signal TransducingBrain-Derived Neurotrophic FactorMC4R protein, humanReceptor, Melanocortin, Type 4
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.