ArticleBMC nutrition2025
The MIND diet, cognitive function, and well-being among healthy adults at midlife: a randomised feasibility trial.
Article in BMC nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04654936 (Feasibility and Acceptability of a 12 Week Online Dietary Intervention Promoting the MIND Diet Using the COM-B Model), which is not on this map. Cited by 5 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility and Acceptability of a 12 Week Online Dietary Intervention Promoting the MIND Diet Using the COM-B Model
Who cites it
5 citing papers in PubMed.
- Observational
- Bias-reduced Regression Analysis in Nutrition (BRAiN) index: self-reported diet and predicted cognitive function.Frontiers in nutrition · 2026Article
- Effects of the MIND Diet on the Cognitive Function of Older Adults: A Systematic Review.Clinical nutrition research · 2025Review
- The long-term neuroprotective effect of MIND and Mediterranean diet on patients with Alzheimer's disease.Scientific reports · 2025Article
- Effects of Dietary Interventions on Cognitive Outcomes.Nutrients · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to slow cognitive decline. However, these diets were not originally developed with dementia prevention as their primary focus. In contrast, the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet was specifically designed based on evidence linking individual dietary components to brain health and the prevention of cognitive decline. The aim of this research was to test the effectiveness of the MIND diet on cognitive function, mood, and quality of life using the Behaviour Change Wheel, and to design an intervention using the COM-B model to promote the MIND diet at midlife.
methodsAn online pilot randomised control trial (RCT) was conducted. Forty-one participants (aged 40-55 years, male and female) were randomised into a MIND diet with support group (n = 15), MIND diet group with no support (n = 14) or control group (n = 12) for 12 weeks. Baseline and follow-up measures of cognitive function, mood, quality of life (QOL) and adherence to MIND diet was assessed in each group. Capability, opportunity, and motivation (COM-B) towards MIND diet behaviour were also assessed pre and post intervention.
resultsA repeated measures ANOVA showed that in comparison to the control group, both intervention groups significantly improved mood, quality of life, MIND diet score and all COM-B components at follow-up (p < 0.05). No significant differences or interactions in cognitive function were found between groups.
conclusionThere are only two RCT's that test the effectiveness of the MIND diet on cognitive function, and this is the first RCT to assess the usefulness of the COM-B in increasing adherence to the MIND diet. Future interventions with longer duration are needed to establish an association with MIND diet and cognitive function in adults at midlife. This study recommends using less Behaviour Change Techniques (BCTs) with a focus on self-monitoring, goal setting and education on diet as an effective strategy for promoting adherence to the MIND diet.
trial registrationTrial registered at ClinicalTrials.gov Protocol Record NCT04654936, May 2019.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.