ArticleThe Journal of neuropsychiatry and clinical neurosciences2026
Hyperorality in Frontotemporal Dementia: How Psychiatric and Neural Correlates Change During the Disease Course.
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Article in The Journal of neuropsychiatry and clinical neurosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Examining neuropsychiatric symptoms and functional decline in behavioral variant frontotemporal dementia.International review of psychiatry (Abingdon, England) · 2025Article
- Neuropsychiatric symptoms cluster and fluctuate over time in behavioral variant frontotemporal dementia.Psychiatry and clinical neurosciences · 2025Article
- Neuropsychiatric Symptoms Cluster and Fluctuate Over Time in Behavioral Variant Frontotemporal Dementia.medRxiv : the preprint server for health sciences · 2024Article
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Authors and funding
24 authors.
Christopher B MorrowDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).ORCID 0000-0003-4600-1802
Chiadi OnyikeDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Alexander PantelyatDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Gwenn S SmithDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Jeannie LeoutsakosDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Andreia V FariaDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Neill R Graff-RadfordDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
R Ryan DarbyDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Nupur GhoshalDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Adam M StaffaroniDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Katya RascovskyDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Toji MiyagawaDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Akshata BalajiDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Kyrana TsapkiniDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Maria I LapidDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Mario F MendezDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).ORCID 0000-0001-6441-7989
Irene LitvanDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Belen PascualDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Julio C RojasDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Zbigniew K WszolekDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Kimiko Domoto-ReillyDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
John KornakDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Vidyulata KamathDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
ALLFTD ConsortiumDepartment of Psychiatry and Behavioral Sciences (Morrow, Onyike, Smith, Leoutsakos, Balaji, Kamath), Department of Neurology (Pantelyat, Tsapkini), and Russell Morgan Department of Radiology (Smith, Faria), Johns Hopkins University School of Medicine, Baltimore; Department of Neurology, Mayo Clinic, Jacksonville, Fla. (Graff-Radford, Wszolek); Department of Neurology, Vanderbilt University Medical Center, Nashville (Darby); Department of Neurology, Washington University School of Medicine, St. Louis (Ghoshal); Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences (Staffaroni, Rojas), and Department of Epidemiology and Biostatistics (Kornak), University of California San Francisco, San Francisco; Department of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine, Philadelphia (Rascovsky); Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minn. (Miyagawa, Lapid); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles (Mendez); Department of Neurosciences, University of California San Diego, La Jolla (Litvan); Department of Neurology, Houston Methodist Research Institute, Houston (Pascual); Department of Neurology, University of Washington School of Medicine, Seattle (Domoto-Reilly).
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI ADAM L. BOXER · 2019 to 2026
$120.9MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MResearch Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3MUniversity of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0MThe Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1MDementia with Lewy Bodies Consortium - Supplement for ASL sequenceU01NS100610 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI DOUGLAS R GALASKO, JAMES Bruce LEVERENZ · 2016 to 2026
$15.6MInstitutional Career Development CoreKL2TR003099 · NCATS · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2019 to 2023
$7.9MBIOMARKER DISCOVERY AND VALIDATION IN PSPU01NS102035 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PANTELYAT, ALEXANDER Y. · 2018 to 2022
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$3.2MTraining in Research to Assure Neuroscience Scholars Cultivate Expertise in Notable Disparities Science (TRANSCENDS)R25NS098999 · NINDS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BRUCE OVBIAGELE · 2017 to 2026
$2.5MProteomics for fluid biomarker discovery in frontotemporal dementiaK23AG059888 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROJAS-MARTINEZ, JULIO CESAR · 2019 to 2023
$995kNCATS NIH HHS KL2 TR003099NIA NIH HHS K23 AG059888NIA NIH HHS K23 AG059891NIA NIH HHS K23 AG088248NIA NIH HHS L30 AG083912NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066509NIA NIH HHS R01 AG038791NIA NIH HHS R01 AG064093NIA NIH HHS U19 AG063911NINDS NIH HHS R01 NS108452NINDS NIH HHS R21 NS114764NINDS NIH HHS R25 NS098999NINDS NIH HHS U01 NS100610NINDS NIH HHS U01 NS102035
Abstract
objectiveHyperorality is a core feature of behavioral variant frontotemporal dementia (bvFTD); however, the cognitive, psychiatric, and neuroanatomical correlates of hyperorality across the bvFTD stages remain unclear. The authors explored these associations in early- and advanced-stage bvFTD.
methodsParticipants with sporadic or genetic bvFTD were enrolled in the ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) consortium study. Baseline cognitive and psychiatric symptoms of participants with or without hyperorality were compared after stratification by disease severity. Linear multivariable regressions adjusted for age and total intracranial volume were used to examine associations between regional gray matter volume (GMV) and hyperorality status. Five anatomical regions of interest were preselected for analysis on the basis of previously identified neuroanatomical correlates of hyperorality in bvFTD.
resultsHyperorality was present in 50% of early-stage bvFTD participants (N=136) and was associated with higher rates of ritualistic-compulsive behavior and difficulty detecting social-emotional expressions. Hyperorality was present in 63% of advanced-stage participants (N=208) and was associated with higher rates of apathy, ritualistic-compulsive behavior, and socially aberrant behavior. Regional GMV was similar for those with or without hyperorality among early-stage participants. Among advanced-stage participants, hyperorality was associated with lower GMV in the right dorsal and ventral striatum.
conclusionsHyperorality emerged early in bvFTD and was accompanied by deficits in social cognition and complex-ritualistic behavior before clinically significant GMV loss. These findings suggest that early identification and management of hyperorality could improve neuropsychiatric trajectories in bvFTD.
Indexed as
BrainFrontotemporal DementiaGray MatterAgedDisease ProgressionFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedFrontotemporal dementiaGeriatric neuropsychiatryHyperoralityNeuroimagingPsychiatric symptoms
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.