Evidence map›Paper›PMID 40134377›Full record

ReviewHistology and histopathology2025

Progress of research on engineered extracellular vesicles from different sources for disease treatment.

Jinhui Kang, Jun Wen, Huifang Chen, Cui Zhu, Yinshan Bai

Abstract readReview
PubMed Publisher
In one paragraph

Review in Histology and histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jinhui KangGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, Foshan University, Foshan, China.
Jun WenGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, Foshan University, Foshan, China.
Huifang ChenGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, Foshan University, Foshan, China.
Cui ZhuGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, Foshan University, Foshan, China.
Yinshan BaiGuangdong Provincial Key Laboratory of Animal Molecular Design and Precision Breeding, Foshan University, Foshan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are lipid bilayer nanoparticles that encapsulate proteins, lipids, nucleic acids, and small molecules and display low immunogenicity, high stability, and cross-species transmission. By applying engineering technologies, the surface of EVs can be modified and loaded with cargo with therapeutic properties. Thus, engineered EVs can play important roles in preventing and treating various diseases. However, many challenges and uncertainties are faced in the clinical translation of EVs. In this review, we comprehensively analyzed the types of EVs derived from animal cells, plant cells, and microorganisms and summarized their biological properties and potential for engineering modifications. Furthermore, we also explored their therapeutic potential and discussed recent advancements in relevant clinical trials, aiming to provide scientific guidance for future research on the engineering of EVs and precision treatment of clinical diseases.

Indexed as

Extracellular VesiclesAnimalsHumans

Identifiers

PMID40134377

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.