Evidence map›Paper›PMID 40134445›Full record

ArticleJournal of medicine and life2025

Spotting the clues: cluster of differentiation-a perspective of immune response intertwined with dysautonomia in colon cancer - a prospective cohort study.

Diana-Theodora Morgos, Lucian-George Eftimie, Horia Nicolae, Remus Iulian Nica, Constantin Stefani, Daniela Miricescu, Adrian Tulin, Florin Mihail Filipoiu

Abstract read
In one paragraph

Article in Journal of medicine and life, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Diana-Theodora MorgosDoctoral School, Discipline of Anatomy, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Lucian-George EftimieDiscipline of Anatomy and Biomechanics, Faculty of Physical Therapy, National University of Physical Education and Sports, Bucharest, Romania.
Horia NicolaeDiscipline of Neurology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Remus Iulian NicaDr. Carol Davila Central Military Emergency University Hospital, Bucharest, Romania.
Constantin StefaniDepartment I of Family Medicine and Clinical Base, Dr. Carol Davila Central Military Emergency University Hospital, Romania.
Daniela MiricescuDiscipline of Biochemistry, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Adrian TulinDiscipline of Anatomy, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Florin Mihail FilipoiuDiscipline of Anatomy, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysautonomia, a parasympathetic-sympathetic imbalance, has clinical and public health consequences. Colon neoplasm is linked to dysautonomia through a complex interplay between the two conditions. In this prospective cohort study, we evaluated 18 patients divided into three groups: six patients with both colon cancer and dysautonomia, six patients with colon cancer without dysautonomia, and six patients with dysautonomia only (control group). Dysautonomia was defined by the presence of orthostatic hypotension, a non-increased or dropped heart rate, and various autonomic symptoms. During abdominal surgery, tissue samples from the celiac ganglion were collected and analyzed using immunohistochemistry (IHC). Our findings revealed a significant correlation between IHC marker expression in colon cancer and dysautonomia (control) (r = 0.927,

Indexed as

Colonic NeoplasmsPrimary DysautonomiasAgedFemaleHumansMaleMiddle AgedProspective Studiescluster of differentiationcolon cancerdysautonomiaimmunohistochemistry

Identifiers

PMID40134445
PMCPMC11932503

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.