ArticleCureus2025
Evaluation of Etiological Causes and Incidence of Pancytopenia: A Case Series from a Tertiary Care Center.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Epidemiological and clinicopathological profile of pancytopenia: A cross-sectional study.Bioinformation · 2026Article
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2 authors.
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Abstract
Background and aim Pancytopenia is a clinical condition characterized by the simultaneous reduction of red blood cells, white blood cells, and platelets. It generally arises from conditions associated with bone marrow dysfunction or increased peripheral consumption of blood cells. Understanding the regional etiological models of pancytopenia is of paramount importance for optimizing diagnostic and therapeutic strategies specific to the local population. This study aimed to identify the etiological causes and examine the distribution of incidence rates in patients presenting with pancytopenia in Istanbul and cases referred from across Turkey. Methods This retrospective study was conducted between January 2008 and November 2010 in the general internal medicine clinic of a tertiary care training and research hospital serving a large population. The study included 112 adult patients newly diagnosed with pancytopenia who had complete clinical and laboratory data. Data were obtained through detailed laboratory analyses, diagnostic tests, and clinical evaluations. Results Of the 112 patients, the female-to-male ratio was 1.8:1, and the mean age was 56.5 years, with the most common age group being 70-79 years (19.6%, n=22). Pancytopenia was most frequently caused by vitamin B12 deficiency and hypersplenism (20.5%, n=23). These were followed by hematological malignancies (acute leukemia, lymphoma, and multiple myeloma) at 16% (n=18), infections and myelodysplastic syndromes at 10.7% (n=12), drug-induced pancytopenia at 5.4% (n=6), systemic lupus erythematosus at 4.5% (n=5), metastatic solid organ tumors at 3.6% (n=4), and aplastic anemia at 1.8% (n=2). Conclusion This study demonstrated that the most common causes of pancytopenia in the evaluated patient group in Istanbul and cases referred from across Turkey were vitamin B12 deficiency and hypersplenism. This finding underscores the importance of prioritizing systemic conditions over hematological malignancies in the diagnostic process. Accurate identification of underlying causes and improved patient management require a structured diagnostic approach involving thorough clinical evaluations and targeted investigations tailored to regional characteristics.
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