ArticleBrain and behavior2025
Cognitive Decline in Patients With Trigeminal Neuralgia: A Resting-State fMRI Study.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Associations Between Multiple Chemosensory Dysfunction and Cognition.International forum of allergy & rhinology · 2026Article
- Resting-state local brain functional synchronization after a single trigger-zone stimulation: with versus without evoked pain in classical trigeminal neuralgia patients.The journal of headache and pain · 2026Article
- Review
- [Aging-Associated Oral Microbiota Dysbiosis and Hypofunction: Their Role in Alzheimer's Disease Pathogenesis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Individualized rs-fMRI reveals brain-circuit heterogeneity and predicts early recurrence in trigeminal neuralgia.Frontiers in psychiatry · 2026Article
- Abnormal Regional Brain Functional Activity and Brain Network Connectivity in Primary Trigeminal Neuralgia Patients: An Activation Likelihood Estimation Meta-Analysis Based on Resting-State fMRI.Journal of pain research · 2026Review
- Downregulation of Neuralized1 in the Hippocampal CA1 Through Reducing CPEB3 Ubiquitination Mediates Synaptic Plasticity Impairment and Cognitive Deficits in Neuropathic Pain.Neuroscience bulletin · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
objectiveThis study utilized functional magnetic resonance imaging (fMRI) data to investigate cognitive function changes in trigeminal neuralgia (TN) patients and healthy controls (HCs), and to elucidate the potential mechanism. MATERIALS AND
methodsThe cognitive function of 34 patients with TN and 30 HCs was evaluated. Afterward, we calculated the amplitude of low-frequency fluctuations (ALFFs), regional homogeneity (ReHo), and degree centrality (DC). These metrics were correlated with cognitive performance using the Spearman correlation analysis.
resultsPatients with TN exhibited diminished cognitive performance compared to HCs. Increased mean ALFF (mALFF) levels were detected in the right temporal pole, superior temporal gyrus, and right insula in individuals with TN. These increases were negatively correlated with cognitive function. In contrast, decreased mALFF values were observed in the right lingual gyrus, bilateral calcarine, and left middle occipital gyrus, which were associated with improved cognitive function. Increased DC values were found in various areas, such as the right temporal pole, superior temporal gyrus, right opercular inferior frontal gyrus, bilateral medial superior frontal gyrus, left supplementary motor area, left anterior cingulum, and right middle cingulum in individuals with TN. These values negatively correlated with cognitive performance.
conclusionTN patients exhibited impairments in multiple cognitive areas, such as attention, memory, executive function, visual perception and executive ability, information processing speed, and motor speed. The metrics ALFF and DC exhibited alterations in TN patients, suggesting that cognitive impairments may be linked to decreased functional activity in specific brain regions. Concurrently, certain cerebral regions may exhibit increased functional activity as a compensatory response to cognitive deficits. These findings hold significant theoretical value and clinical application potential, providing novel methodologies and perspectives for early diagnosis, personalized treatment, and efficacy evaluation. Such advancements are poised to enhance the overall treatment outcomes and quality of life for TN patients.
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