Evidence mapPaperPMID 40135739Full record

ArticleeLife2025

AI-based discovery and cryoEM structural elucidation of a K

Assmaa Elsheikh, Camden M Driggers, Ha H Truong, Zhongying Yang, John Allen, Niel M Henriksen, Katarzyna Walczewska-Szewc, Show-Ling Shyng

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Assmaa ElsheikhDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, United States.
Camden M DriggersDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, United States.ORCID https://orcid.org/0000-0002-2105-7175
Ha H TruongAtomwise Inc, San Francisco, United States.
Zhongying YangDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, United States.
John AllenDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, United States.
Niel M HenriksenAtomwise Inc, San Francisco, United States.
Katarzyna Walczewska-SzewcInstitute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Toruń, Toruń, Poland.
Show-Ling ShyngDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, United States.ORCID https://orcid.org/0000-0002-8230-8820

Funding

Correlating structure and function in KATP channel isoformsR01GM145784 · OREGON HEALTH & SCIENCE UNIVERSITY · 2025 to 2025
$337k
Egyptian government predoctoral scholarship GM1109NIGMS NIH HHS R01 GM145784NIGMS NIH HHS R01GM145784NIGMS NIH HHS U24 GM129547NIH HHS U24GM129547Polish high-performance computing infrastructure PLGrid PLL/2023/04/016512
6 · The paper itself

Abstract

Pancreatic K

Indexed as

KATP ChannelsAnimalsCongenital HyperinsulinismCryoelectron MicroscopyDrug DiscoveryHumansKATP ChannelsATP-sensitive potassium channelbiochemistrychemical biologycryoEM structuredrug discoveryhumanMesocricetus auratusmolecular biophysicspharmacological chaperonesratstructural biology

Identifiers

PMID40135739
PMCPMC11942174

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.