Evidence map›Paper›PMID 40135829›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia-Induced Vascular Injury.

Anqi Luo, Rui Wang, Jingwen Gong, Shuting Wang, Chuan Yun, Zongcun Chen, Yanan Jiang, Xiaoquan Liu, Haofu Dai, Haochen Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anqi LuoSchool of Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Rui WangKey Laboratory of Hainan Trauma and Disaster Rescue, Hainan Medical University, Haikou, 571199, China.
Jingwen GongSchool of Pharmacy, Hainan Medical University, Haikou, 571199, China.
Shuting WangSchool of Pharmacy, Hainan Medical University, Haikou, 571199, China.
Chuan YunClinical Research Center for Metabolic Disease, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102, China.
Zongcun ChenDepartment of Endocrinology, The Second Affiliated Hospital of Hainan Medical University, Haikou, 570311, China.
Yanan JiangDepartment of Pharmacy, The Second Affiliated Hospital of Hainan Medical University, Haikou, 570311, China.
Xiaoquan LiuSchool of Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Haofu DaiHainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Chinese Academy of Tropical Agriculture Sciences, Haikou, 571101, China.
Haochen LiuSchool of Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Yunsi ZhengKey Laboratory of Hainan Trauma and Disaster Rescue, Hainan Medical University, Haikou, 571199, China.ORCID https://orcid.org/0009-0004-4518-9748

Funding

National Natural Science Foundation of China 81773806National Natural Science Foundation of China 81903703Natural Science Foundation of Hainan Province 821MS138Natural Science Foundation of Hainan Province 821QN403Natural Science Foundation of Hainan Province 822RC821Natural Science Foundation of Hainan Province 824QN263Natural Science Foundation of Hainan Province 824QN272
6 · The paper itself

Abstract

The risk of diabetic cardiovascular complications is closely linked to the length of hyperglycemia exposure. Mitophagy plays a significant role in vascular endothelial injury. However, the specific mechanisms by which mitophagy contributes to endothelial injury during sustained hyperglycemia remain unclear. In diabetic ApoE

Indexed as

HyperglycemiaMitophagyQa-SNARE ProteinsVascular System InjuriesAnimalsApoptosisHumansHuman Umbilical Vein Endothelial CellsMiceMitochondriaReactive Oxygen SpeciesUbiquitin-Protein Ligasesparkin proteinQa-SNARE ProteinsReactive Oxygen SpeciesUbiquitin-Protein Ligases(diabetesFis1mitophagySyntaxin 17)vascular endothelial injury

Identifiers

PMID40135829
PMCPMC12097103

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.