ArticleDevelopment (Cambridge, England)2025
GATA factor Serpent promotes phagocytosis in non-professional phagocytes during Drosophila oogenesis.
Article in Development (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Ecdysone regulates phagocytic cell fate of epithelial cells in developing Drosophila eggs.The Journal of cell biology · 2025Article
- Sacrificing cells of the cyst: non-apoptotic cell death in germline cysts via acidification.Frontiers in cell death · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Clearance of dying cells is essential for tissue homeostasis and requires both professional and non-professional phagocytes; however, it is unclear what promotes phagocytosis by non-professional phagocytes. Follicle cells of Drosophila egg chambers function as non-professional phagocytes to clear large germ cell debris in mid and late oogenesis, providing an excellent model for the study of non-professional phagocytes. Here, we demonstrate that GATA factor Serpent (Srp) plays an indispensable role in promoting the phagocytic capacity of follicle cells in both processes. Srp is upregulated in follicle cells of degenerating mid-stage egg chambers, and its knockdown results in incomplete clearance of germ cell debris and premature follicle cell death. In addition, Srp is upregulated in stretch follicle cells and is essential for clearing the nurse cell nuclei in late oogenesis. Genetic analysis reveals that Srp acts downstream of JNK signaling to upregulate the expression of the phagocytic receptor Draper as well as other components in the corpse processing machinery. Our findings highlight the crucial role for Srp in non-professional phagocytes during Drosophila oogenesis, which may also be conserved across species.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.