Evidence map›Paper›PMID 40136618›Full record

ArticleDiseases (Basel, Switzerland)2025

Lifestyle and Biochemical Parameters That May Hamper Immune Responses in Pediatric Patients After Immunization with the BNT162b2 mRNA COVID-19 Vaccine.

Anthie Damianaki, Antonios Marmarinos, Margaritis Avgeris, Dimitrios Gourgiotis, Elpis-Athina Vlachopapadopoulou, Marietta Charakida, Maria Tsolia, Lydia Kossiva

Abstract read
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In one paragraph

Article in Diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anthie DamianakiSecond Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Children's Hospital P. and A. Kyriakou, 115 27 Athens, Greece.ORCID 0000-0002-2146-8644
Antonios MarmarinosLaboratory of Clinical Biochemistry-Molecular Diagnostics, Second Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Children's Hospital P. and A. Kyriakou, 115 27 Athens, Greece.
Margaritis AvgerisLaboratory of Clinical Biochemistry-Molecular Diagnostics, Second Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Children's Hospital P. and A. Kyriakou, 115 27 Athens, Greece.ORCID 0000-0002-2135-9886
Dimitrios GourgiotisLaboratory of Clinical Biochemistry-Molecular Diagnostics, Second Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Children's Hospital P. and A. Kyriakou, 115 27 Athens, Greece.
Elpis-Athina VlachopapadopoulouDepartment of Endocrinology-Growth and Development, Children's Hospital P. and A. Kyriakou, 115 27 Athens, Greece.ORCID 0000-0001-5641-7081
Marietta CharakidaSecond Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Children's Hospital P. and A. Kyriakou, 115 27 Athens, Greece.
Maria TsoliaSecond Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Children's Hospital P. and A. Kyriakou, 115 27 Athens, Greece.ORCID 0000-0003-2485-4409
Lydia KossivaSecond Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Children's Hospital P. and A. Kyriakou, 115 27 Athens, Greece.ORCID 0000-0002-0476-6586

Funding

BANK OF GREECE 5000 EURO
6 · The paper itself

Abstract

backgroundThe aim of this study was to evaluate whether increased body mass index (BMI) and biochemical and lifestyle parameters linked to obesity and smoke exposure disrupt immune responses of children and adolescents following vaccination with the mRNA BNT162b2 vaccine.

methodsA prospective, single-center, cohort study was conducted. Participants were assigned to receive two doses of the mRNA vaccine. Anti-SARS-CoV-2 IgG and neutralizing antibodies (AB) were measured before vaccination (T0) and 14 days after the second dose (T1). BMI and biochemical parameters were evaluated at T0. A questionnaire on lifestyle characteristics was filled in.

resultsIgG optical density (OD) ratio at T1 was lower in the overweight-obese group regardless of COVID-19 disease positive history [

conclusionsCurrent data suggests that uric acid, insulin resistance (IR), and smoke exposure could adversely affect the immune responses in overweight-obese vaccinated children, highlighting the need for actions to enhance the protection of this particular subgroup.

Indexed as

BMIhumoral immunityinsulin resistancemRNA vaccineobesityuric acid

Identifiers

PMID40136618
PMCPMC11940919

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.