Evidence map›Paper›PMID 40136697›Full record

ReviewCells2025

The Recovery of Epidermal Proliferation Pattern in Human Skin Xenograft.

Olga Cherkashina, Alexandra Tsitrina, Danila Abolin, Elena Morgun, Anastasiya Kosykh, Marat Sabirov, Ekaterina Vorotelyak, Ekaterina Kalabusheva

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Tissue barriers · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Olga CherkashinaKoltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Alexandra TsitrinaIlse Katz Institute of Nanoscale Science, Ben Gurion University of the Negev, Beer Sheva 8410501, Israel.ORCID 0000-0002-2827-9993
Danila AbolinKoltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Elena MorgunKoltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Anastasiya KosykhCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.ORCID 0000-0002-2908-6499
Marat SabirovKoltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0002-7250-4852
Ekaterina VorotelyakKoltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0001-5405-0212
Ekaterina KalabushevaKoltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0002-6987-0683

Funding

Russian Science Foundation 21-74-30015-π
6 · The paper itself

Abstract

Abnormalities in epidermal keratinocyte proliferation are a characteristic feature of a range of dermatological conditions. These include hyperproliferative states in psoriasis and dermatitis as well as hypoproliferative states in chronic wounds. This emphasises the importance of investigating the proliferation kinetics under conditions of healthy skin and identifying the key regulators of epidermal homeostasis, maintenance, and recovery following wound healing. Animal models contribute to our understanding of human epidermal self-renewal. Human skin xenografting overcomes the ethical limitations of studying human skin during regeneration. The application of this approach has allowed for the identification of a single population of stem cells and both slowly and rapidly cycling progenitors within the epidermal basal layer and the mapping of their location in relation to rete ridges and hair follicles. Furthermore, we have traced the dynamics of the proliferation pattern reorganization that occurs during epidermal regeneration, underlining the role of YAP activity in epidermal relief formation.

Indexed as

EpidermisHeterograftsSkinAnimalsCell ProliferationHumansKeratinocytesRegenerationWound Healinghuman skin xenograftkeratinocyte proliferationskin regenerationskin stem cells

Identifiers

PMID40136697
PMCPMC11941497

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.