Evidence map›Paper›PMID 40136708›Full record

ReviewCells2025

Ciliary Ion Channels in Polycystic Kidney Disease.

Lubna A Alshriem, Raghad Buqaileh, Qasim Alorjani, Wissam AbouAlaiwi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lubna A AlshriemDepartment of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA.ORCID 0000-0001-5278-5311
Raghad BuqailehDepartment of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA.
Qasim AlorjaniDepartment of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA.
Wissam AbouAlaiwiDepartment of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA.ORCID 0000-0002-8226-3108

Funding

Program to Increase Diversity in Cardiovascular Health-Related Research(PRIDE-CVD)R25HL105446 · NHLBI · SUNY DOWNSTATE MEDICAL CENTER · 2023 to 2025
$1.0M
NHLBI NIH HHS R25 HL105446NIA NIH HHS R03 AG080418
6 · The paper itself

Abstract

Polycystic kidney disease (PKD) is the most common hereditary disorder that disrupts renal function and frequently progresses to end-stage renal disease. Recent advances have elucidated the critical role of primary cilia and ciliary ion channels, including transient receptor potential (TRP) channels, cystic fibrosis transmembrane conductance regulator (CFTR), and polycystin channels, in the pathogenesis of PKD. While some channels primarily function as chloride conductance channels (e.g., CFTR), others primarily regulate calcium (Ca

Indexed as

CiliaIon ChannelsPolycystic Kidney DiseasesAnimalsCystic Fibrosis Transmembrane Conductance RegulatorHumansTRPP Cation ChannelsCystic Fibrosis Transmembrane Conductance RegulatorIon ChannelsTRPP Cation ChannelsCa+2CFTRion channelspolycystic kidney diseasepolycystinprimary ciliaTRPV4

Identifiers

PMID40136708
PMCPMC11941060

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.