Evidence map›Paper›PMID 40137419›Full record

ArticleJournal of personalized medicine2025

Genetic and Regulatory Mechanisms of Comorbidity of Anxiety, Depression and ADHD: A GWAS Meta-Meta-Analysis Through the Lens of a System Biological and Pharmacogenomic Perspective in 18.5 M Subjects.

Kai-Uwe Lewandrowski, Kenneth Blum, Alireza Sharafshah, Kyriaki Z Thanos, Panayotis K Thanos, Richa Zirath, Albert Pinhasov, Abdalla Bowirrat, Nicole Jafari, Foojan Zeine and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Kai-Uwe LewandrowskiDivision of Personalized Medicine, Center for Advanced Spine Care of Southern Arizona, Tucson, AZ 85712, USA.ORCID 0000-0001-7842-2914
Kenneth BlumDivision of Personalized Medicine, Center for Advanced Spine Care of Southern Arizona, Tucson, AZ 85712, USA.ORCID 0000-0001-6727-803X
Alireza SharafshahCellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht 4144666949, Iran.ORCID 0000-0001-8048-9587
Kyriaki Z ThanosBehavioral Neuropharmacology & Neuroimaging Laboratory on Addictions (BNNLA), Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA.
Panayotis K ThanosDepartment of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel 40700, Israel.
Richa ZirathBehavioral Neuropharmacology & Neuroimaging Laboratory on Addictions (BNNLA), Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA.
Albert PinhasovDepartment of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel 40700, Israel.ORCID 0000-0001-8116-4565
Abdalla BowirratDepartment of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel 40700, Israel.ORCID 0000-0001-8185-0688
Nicole JafariDepartment of Applied Clinical Psychology, The Chicago School of Professional Psychology, Los Angeles, CA 60601, USA.ORCID 0000-0001-7762-9673
Foojan ZeineDepartment of Health Science, California State University at Long Beach, Long Beach, CA 90815, USA.ORCID 0009-0006-7709-5580
Milan MakaleDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-0507-5883
Colin HannaBehavioral Neuropharmacology & Neuroimaging Laboratory on Addictions (BNNLA), Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA.
David BaronDivision of Addiction Research & Education, Center for Sports, Exercise, Psychiatry, Western University Health Sciences, Pomona, CA 91766-1854, USA.
Igor ElmanDepartment of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel 40700, Israel.
Edward J ModestinoBrain & Behavior Laboratory, Department of Psychology, Curry College, Milton, MA 02186, USA.ORCID 0000-0001-7611-5144
Rajendra D BadgaiyanDepartment of Psychiatry, Texas Tech University Health Sciences, School of Medicine, Midland, TX 79430, USA.ORCID 0000-0001-5586-5114
Keerthy SunderDivision of Addiction Research & Education, Center for Sports, Exercise, Psychiatry, Western University Health Sciences, Pomona, CA 91766-1854, USA.
Kevin T MurphyDivision of Personalized Neuromodulations, PeakLogic, Del Mar, CA 92130, USA.
Ashim GuptaThe Kenneth Blum Behavioral & Neurogenetic Institute, Austin, TX 78701, USA.ORCID 0000-0003-1224-2755
Alex P L LewandrowskiInstitute of Psychology, ELTE Eötvös Loránd University, H-1117 Budapest, Hungary.
Rossano Kepler Alvim FiorelliPrograma de Pós-Graduação em Neurologia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 20270-004, Brazil.ORCID 0000-0001-5236-0903
Sergio SchmidtPrograma de Pós-Graduação em Neurologia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 20270-004, Brazil.ORCID 0000-0001-7654-5507

Funding

Prenatal Tobacco and Cannabis Exposure: A Translational StudyR33DA045640 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI EIDEN, RINA D, THANOS, PANAYOTIS K · 2021 to 2023
$999k
Prenatal Tobacco and Cannabis Exposure: A Translational StudyR21DA045640 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI EIDEN, RINA D, THANOS, PANAYOTIS K · 2018 to 2019
$434k
A Systematic Medical Approach to Reward Transformation (SMART) for Brain Health in Opioid Use DisorderR41MD012318 · NIMHD · VERSA INTEGRATED SOLUTIONS, INC. · PI BLUM, KENNETH, GONDRE-LEWIS, MARJORIE C · 2017 to 2017
$221k
CSRD VA I01 CX000479CSRD VA I01 CX002099NIDA NIH HHS R21 DA045640NIDA NIH HHS R33 DA045640NIMHD NIH HHS R41 MD012318
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ADHDanxietyautism spectrum disorder (ASD)depressiondopamine dysregulationepigeneticsgenesGWASpharmacogenomics (PGx)reward deficiency syndrome (RDS)

Identifiers

PMID40137419
PMCPMC11943124

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.