Evidence map›Paper›PMID 40137423›Full record

ArticleJournal of personalized medicine2025

Dysregulation of Circadian Markers, HAT1 and Associated Epigenetic Proteins, and the Anti-Aging Protein KLOTHO in Placenta of Pregnant Women with Chronic Venous Disease.

Oscar Fraile-Martinez, Cielo García-Montero, Tatiana Pekarek, Julia Bujan, Silvestra Barrena-Blázquez, Eva Manuela Pena-Burgos, Laura López-González, Leonel Pekarek, Raul Díaz-Pedrero, Juan A De León-Luis and 5 more

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Oscar Fraile-MartinezDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Networking Research Center on for Liver and Digestive Diseases (CIBEREHD), 28801 Alcala de Henares, Spain.ORCID 0000-0002-4494-6397
Cielo García-MonteroDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Networking Research Center on for Liver and Digestive Diseases (CIBEREHD), 28801 Alcala de Henares, Spain.ORCID 0000-0001-6016-7855
Tatiana PekarekDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Networking Research Center on for Liver and Digestive Diseases (CIBEREHD), 28801 Alcala de Henares, Spain.
Julia BujanDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Networking Research Center on for Liver and Digestive Diseases (CIBEREHD), 28801 Alcala de Henares, Spain.ORCID 0000-0003-2419-2476
Silvestra Barrena-BlázquezRamón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.ORCID 0000-0003-2715-1979
Eva Manuela Pena-BurgosPathological Anatomy Service, University Hospital Gregorio Marañón, 28009 Madrid, Spain.ORCID 0000-0001-7113-045X
Laura López-GonzálezRamón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.
Leonel PekarekDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Networking Research Center on for Liver and Digestive Diseases (CIBEREHD), 28801 Alcala de Henares, Spain.
Raul Díaz-PedreroRamón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.ORCID 0000-0003-0412-939X
Juan A De León-LuisDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0002-6320-2668
Coral BravoDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
Melchor Álvarez-MonDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Networking Research Center on for Liver and Digestive Diseases (CIBEREHD), 28801 Alcala de Henares, Spain.ORCID 0000-0003-1309-7510
Miguel A SaezDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Networking Research Center on for Liver and Digestive Diseases (CIBEREHD), 28801 Alcala de Henares, Spain.ORCID 0000-0002-8389-258X
Natalio García-HonduvillaDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Networking Research Center on for Liver and Digestive Diseases (CIBEREHD), 28801 Alcala de Henares, Spain.ORCID 0000-0003-0904-6198
Miguel A OrtegaDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Networking Research Center on for Liver and Digestive Diseases (CIBEREHD), 28801 Alcala de Henares, Spain.ORCID 0000-0003-2588-1708

Funding

COMUNIDAD DE MADRID MITIC-CM
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

agingchronic venous disease (CVD)circadian alterationsepigenetic changeshistopathologyplacentapregnancy

Identifiers

PMID40137423
PMCPMC11943174

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.