Evidence map›Paper›PMID 40137814›Full record

ArticleTropical medicine and infectious disease2025

Sex-Specific Immune Responses Mediate Host Specificity in Hookworm Infections.

Andrea Langeland, Catherine A Jackson, Elise L McKean, Hajar Errahmani, Damien M O'Halloran, John M Hawdon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tropical medicine and infectious disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrea LangelandDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0001-5132-6420
Catherine A JacksonDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC 20052, USA.
Elise L McKeanDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC 20052, USA.
Hajar ErrahmaniDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC 20052, USA.
Damien M O'HalloranDepartment of Biological Sciences, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0001-5752-2131
John M HawdonDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0002-6164-1413

Funding

Harlan Endowment N/ANational Institute of Allergy and Infectious Diseases of the National Institutes of Health R21AI173403-02
6 · The paper itself

Abstract

Hookworm infections affect 500-700 million people worldwide and can lead to chronic conditions, such as malnutrition and anemia. The challenge of managing these infections is heightened by the absence of effective vaccines and the potential for anthelmintic resistance to develop. A comprehensive understanding of the molecular interactions between the parasite and host is vital for unraveling the complexities of infection dynamics. This study aimed to identify the immune system components responsible for host specificity in hookworms by infecting immunodeficient mouse models. Findings herein indicate that innate immunity is essential in protecting against

Indexed as

Ancylostoma caninumAncylostoma ceylanicumhookworm infectionshost specificityinnate immunitymouse modelsStat6 pathway

Identifiers

PMID40137814
PMCPMC11945332

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.