ArticleMolecular biology of the cell2025
Spatial and temporal signatures of cell competition revealed by K-function analysis.
Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cell competition is often categorized into mechanical competition, during which loser cell elimination is induced by long-range mechanical effects, and biochemical competition, during which loser cell elimination results from direct cell-cell contacts. Before confluence, proliferation of winner cells has often been hypothesized to govern competition. Conversely, elimination of loser cells is thought to induce cell proliferation in its vicinity. However, causality is challenging to establish. To address this, we compute spatiotemporal signatures of competitive interactions using K-function clustering analysis. For this, we acquire long-term time lapses of two examples of mechanical (Scr
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