ArticleCurrent microbiology2025
Sublethal Curcumin Exposure Induces Global Gene Expression and Biofilm-Related Phenotypic Changes in Vibrio parahaemolyticus.
Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Antimicrobial and anti-biofilm activity of Epigallocatechin gallate against Vibrio parahaemolyticus.NPJ science of food · 2026Article
- Functional divergence and regulatory network of the type VI secretion system inJournal of bacteriology · 2026Review
- Investigating c-di-GMP Signaling in Vibrio parahaemolyticus: Biological Effects and Mechanisms of Regulation.Current microbiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Vibrio parahaemolyticus, a foodborne pathogen found in marine environments, is susceptible to the antimicrobial effects of curcumin-a lipophilic polyphenolic pigment with diverse biological activities. While sublethal doses of curcumin inhibit behaviors of V. parahaemolyticus, the underlying molecular mechanisms remain poorly characterized. In this study, we aimed to investigate the impact of sublethal doses of curcumin on gene expression and key bacterial processes in V. parahaemolyticus. RNA sequencing (RNA-seq) revealed that sublethal curcumin concentrations significantly suppressed bacterial growth and altered the expression of 788 genes. These differentially expressed genes (DEGs) were associated with critical pathways, including upregulated systems such as polar flagellum, type IV pili, and type VI secretion systems (T6SS1 and T6SS2), as well as downregulated systems such as lateral flagella, exopolysaccharides (EPS), and type III secretion systems (T3SS1 and T3SS2). Notably, most DEGs involved in cyclic di-GMP (c-di-GMP) metabolism were downregulated, while putative porin-related genes were upregulated. Additionally, sublethal curcumin significantly inhibited biofilm formation and swimming motility but enhanced c-di-GMP production in V. parahaemolyticus. This study provides valuable insights into how V. parahaemolyticus adjusts its gene expression in response to sublethal levels of curcumin.
Indexed as
Identifiers
40137992What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.