ReviewCellular and molecular neurobiology2025
Genetic, Epigenetic, and Hormonal Regulation of Stress Phenotypes in Major Depressive Disorder: From Maladaptation to Resilience.
Review in Cellular and molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- miR-34 regulates stress-induced depression-like state through theResearch square · 2026Article
- Association Between Biochemical, Inflammatory, Oxidative Stress and DNA Methylation Biomarkers with Perceived Stress in Mexican Individuals.Biomolecules · 2026Article
- The Genetic Mosaic of Depression: Linking Polymorphisms to Neuroplasticity and Stress Regulation.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Aberrant MicroRNA-124 expression and methylation in the dorsolateral prefrontal cortex of depressed subjects.Journal of psychiatric research · 2026Article
- Bridging reward and resilience: the endocannabinoid system as a unifying mechanism in exercise-induced protection against major depressive disorder.Frontiers in psychiatry · 2026Review
- Correlation Between Food Habits and Mental Disorders in the Adult Population of São Paulo City, Brazil: A Cross-Sectional Study.Health science reports · 2025Article
- The Skin-Brain Axis in Psoriasis and Depression: Roles of Inflammation, Hormones, Neuroendocrine Pathways, Neuropeptides, and the Microbiome.Psoriasis (Auckland, N.Z.) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major Depressive Disorder (MDD) is a complex psychiatric disorder with varied molecular mechanisms underlying its aetiology, diagnosis, and treatment. This review explores the crucial roles of stress, genetics, epigenetics, and hormones in shaping susceptibility and resilience to mood disorders. We discuss how acute stress can be beneficial, while prolonged stress disrupts brain function, leading to MDD. The review also highlights the significance of various animal models in understanding depression pathophysiology, including zebrafish, mice, and rats, which exhibit distinct sex differences in stress responses. Furthermore, we delve into the molecular bases of susceptible and resilient phenotypes, focusing on genetic aspects such as gene polymorphisms, mutations, and telomere length alterations. The review also examines epigenetic aspects including DNA methylation, histone acetylation and deacetylation, histone methylation and HMTs, and miRNA, which contribute to the development of MDD. Additionally, we explore the role of hormones such as estrogen, progesterone, and prolactin in modulating stress responses and influencing MDD susceptibility and resilience. Finally, we discuss the clinical implications of these findings, including recent clinical methods for determining MDD susceptibility and resiliency phenotypes. By consolidating the current knowledge and insights, this review aims to provide a comprehensive understanding of the molecular basis of susceptibility and resilience in mood disorders, contributing to the ongoing efforts in combating this debilitating disorder.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.