Evidence map›Paper›PMID 40138433›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Lifespan of male and female APP/PS1 and APP

Hannah Roberts, Yimin Fang, Kathleen Quinn, Tiarra Hill, Mackenzie R Peck, Andrzej Bartke, Kevin N Hascup, Erin R Hascup

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Hannah RobertsNeuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Departments of Neurology, Southern Illinois University School of Medicine, Springfield, IL, USA.ORCID 0009-0002-2955-6515
Yimin FangNeuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Departments of Neurology, Southern Illinois University School of Medicine, Springfield, IL, USA.ORCID 0000-0001-9270-5857
Kathleen QuinnNeuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Departments of Neurology, Southern Illinois University School of Medicine, Springfield, IL, USA.
Tiarra HillNeuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Departments of Neurology, Southern Illinois University School of Medicine, Springfield, IL, USA.ORCID 0009-0000-7995-842X
Mackenzie R PeckNeuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Departments of Neurology, Southern Illinois University School of Medicine, Springfield, IL, USA.ORCID 0000-0002-2611-1150
Andrzej BartkeInternal Medicine, Southern Illinois University School of Medicine, Springfield, IL, USA.ORCID 0000-0002-2569-557X
Kevin N HascupNeuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Departments of Neurology, Southern Illinois University School of Medicine, Springfield, IL, USA.ORCID 0000-0001-6604-1874
Erin R HascupNeuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Departments of Neurology, Southern Illinois University School of Medicine, Springfield, IL, USA.ORCID 0000-0003-1037-0809

Funding

Sequelae of SARS-CoV-2 Infection in Alzheimer's DiseaseR01AG061937 · NIA · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · PI HASCUP, ERIN R · 2018 to 2022
$4.0M
Glutamate neurotransmission in Alzheimer's disease progressionR01AG057767 · NIA · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · PI HASCUP, ERIN R · 2018 to 2022
$3.2M
NIA NIH HHS R01 AG057767NIA NIH HHS R01 AG061937
6 · The paper itself

Abstract

Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APP

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorLongevityPresenilin-1Sex CharacteristicsAnimalsDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMice, TransgenicAmyloid beta-Protein PrecursorPresenilin-1Alzheimer's diseaseamyloid-βKaplan-Meier estimatesurvival curve

Identifiers

PMID40138433
PMCPMC12376845

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.