Evidence map›Paper›PMID 40138454›Full record

ArticleScience translational medicine2025

Tick feeding or vaccination with tick antigens elicits immunity to the

Thomas M Hart, Yingjun Cui, Sam R Telford, Alejandro Marín-López, Keith Calloway, Yile Dai, Jaqueline Matias, Kathleen DePonte, Jillian Jaycox, Melody DeBlasio and 11 more

Abstract read
In one paragraph

Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Immunization with mRNA-LNPs EncodingPathogens (Basel, Switzerland) · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Thomas M HartSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0001-5949-9932
Yingjun CuiSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-7416-0934
Sam R TelfordDepartment of Infectious Disease and Global Health, Tufts Lyme Disease Initiative, Tufts University, North Grafton, MA 01536, USA.
Alejandro Marín-LópezSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-2840-1722
Keith CallowaySection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Yile DaiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-7761-3361
Jaqueline MatiasSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-8056-2825
Kathleen DePonteSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0009-0001-3954-6735
Jillian JaycoxDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-0919-5679
Melody DeBlasioSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Dieuwertje HoornstraDepartment of Internal Medicine, Division of Infectious Diseases & Center for Experimental and Molecular Medicine, Amsterdam UMC, Amsterdam 1105 AZ, Netherlands.ORCID 0000-0003-0347-2049
Alexia A BelperronSection of Rheumatology, Allergy & Immunology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Balasubramanian CibichakravarthySection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-2814-8870
Emily E JohnsonSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0001-8189-8788
Mohamad-Gabriel AlamehPenn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.ORCID 0000-0002-5672-6930
Garima DwivediPenn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.
Joppe W R HoviusDepartment of Internal Medicine, Division of Infectious Diseases & Center for Experimental and Molecular Medicine, Amsterdam UMC, Amsterdam 1105 AZ, Netherlands.ORCID 0000-0003-0066-2437
Linda K BockenstedtSection of Rheumatology, Allergy & Immunology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0001-9349-8757
Drew WeissmanPenn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.ORCID 0000-0002-1501-6510
Aaron M RingDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-3699-2446
Erol FikrigSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-5884-6047

Funding

Systems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI Albert C Shaw · 2010 to 2026
$50.4M
Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Erol Fikrig, UTPAL PAL · 2018 to 2026
$13.5M
A novel Lyme disease vaccineR01AI165499 · NIAID · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR, FIKRIG, EROL · 2022 to 2025
$3.2M
The role of tick gut microbiota in Borrelia burgdorferi transmission to miceR01AI126033 · NIAID · YALE UNIVERSITY · PI FIKRIG, EROL, NARASIMHAN, SUKANYA · 2017 to 2020
$1.7M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2M
NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI126033NIAID NIH HHS R01 AI165499NIAID NIH HHS U19 AI089992NIH HHS S10 OD030363
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AntigensFeeding BehaviorIxodesProteomeVaccinationAnimalsFemaleGuinea PigsHumansImmunoglobulin GLyme DiseaseMiceTick BitesAntigensImmunoglobulin GProteome

Identifiers

PMID40138454
PMCPMC12067475

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.