Evidence map›Paper›PMID 40139410›Full record

ReviewBiochimica et biophysica acta. Molecular basis of disease2025

Impact of Sorbs2 dysfunction on cardiovascular diseases.

Xiaowei Xiong, Hon-Chi Lee, Tong Lu

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta. Molecular basis of disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiaowei XiongThe Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America.
Hon-Chi LeeThe Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America.
Tong LuThe Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America. Electronic address: lu.tong@mayo.edu.

Funding

Sorbs2 targeting and BK channel regulation in the coronary artery of patients with type 1 diabetesR01HL161821 · NHLBI · MAYO CLINIC ROCHESTER · PI Tong Lu · 2022 to 2026
$2.7M
NHLBI NIH HHS R01 HL161821
6 · The paper itself

Abstract

Despite significant advancements in prevention and treatment over the past decades, cardiovascular diseases (CVDs) remain the leading cause of death worldwide. CVDs involve multifactorial inheritance, but our understanding of the genetic impact on these diseases is still incomplete. Sorbin and SH3 domain-containing protein 2 (Sorbs2) is ubiquitously expressed in various tissues, including the cardiovascular system. Increasing evidence suggests that Sorbs2 malfunction contributes to CVDs. This manuscript will review our current understanding of the potential mechanisms underlying Sorbs2 dysregulation in the development of CVDs.

Indexed as

Adaptor Proteins, Signal TransducingCardiovascular DiseasesMicrofilament ProteinsAnimalsHumansAdaptor Proteins, Signal TransducingMicrofilament ProteinsCardiovascular diseasePathophysiologySorbs2

Identifiers

PMID40139410
PMCPMC12037213

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.