Evidence map›Paper›PMID 40139413›Full record

ArticleFree radical biology & medicine2025

Experiences of multiple psychosocial stressors and associations with oxidative stress biomarkers during pregnancy.

Stephanie M Eick, Manuela L Celia-Sanchez, Tracey J Woodruff, Dana E Goin, Amy M Padula, Lara Cushing, Kaegan Ortlund, Erin DeMicco, Ginger L Milne, Rachel Morello-Frosch

Abstract read
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In one paragraph

Article in Free radical biology & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stephanie M EickGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, USA. Electronic address: stephanie.marie.eick@emory.edu.
Manuela L Celia-SanchezGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, USA.
Tracey J WoodruffProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, USA.
Dana E GoinDepartment of Epidemiology, Mailman School of Public Health, Columbia University, USA.
Amy M PadulaProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, USA.
Lara CushingDepartment of Environmental Health, School of Public Health, University of California, Los Angeles, USA.
Kaegan OrtlundGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, USA.
Erin DeMiccoProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, USA.
Ginger L MilneDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, USA.
Rachel Morello-FroschProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, USA; Department of Environmental Science, Policy and Management and School of Public Health, University of California, Berkeley, USA.

Funding

Oversight and Project Management ComponentU2COD023375 · DUKE UNIVERSITY · 2025 to 2025
$26.2M
The Illinois Kids Development Study ECHO Pregnancy and Pediatric CohortUH3OD023272 · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2025 to 2025
$2.0M
UCSF Environmental Research and Translation for Health Center (EaRTH Center)P30ES030284 · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2025 to 2025
$1.6M
HERCULES: Exposome Research CenterP30ES019776 · EMORY UNIVERSITY · 2025 to 2025
$1.6M
NIEHS NIH HHS P01 ES022841NIEHS NIH HHS P30 ES019776NIEHS NIH HHS P30 ES030284NIH HHS U2C OD023375NIH HHS UG3 OD023272NIH HHS UH3 OD023272
6 · The paper itself

Abstract

backgroundOxidative stress is hypothesized to be one mechanism linking psychosocial stressor exposure to preterm birth and other adverse pregnancy outcomes. However, prior studies have focused solely on singular psychosocial stressors, which may not reflect real world exposures as pregnant women may experience multiple stressors simultaneously.

methodsParticipants included a subset of the Chemicals in Our Bodies cohort, a prospective birth cohort in San Francisco, California (N = 227). Self -reported psychosocial stressors were assessed via questionnaires administered during the second trimester that addressed financial strain, food insecurity, job strain, neighborhood quality, caregiving, stressful life events, unplanned pregnancy, and perceived community status. Oxidative stress biomarkers were measured during the second trimester of pregnancy and included 15-F

results15-F

conclusionsUrinary oxidative stress biomarkers were elevated among pregnant women exposed to psychosocial stressors, and exposure to multiple stressors resulted in the strongest associations. These findings support oxidative stress as one potential biological pathway linking prenatal psychosocial stress to preterm birth and other adverse pregnancy outcomes.

Indexed as

Oxidative StressPremature BirthStress, PsychologicalAdultBiomarkersFemaleHumansPregnancyPregnancy Trimester, SecondProspective StudiesBiomarkersIsoprostanesPregnancyPsychosocial stress

Identifiers

PMID40139413
PMCPMC12045721

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.