Evidence map›Paper›PMID 40139482›Full record

Observational studyThe Journal of nutrition2025

Serum 25-Hydroxyvitamin D and Intact Parathyroid Hormone as Functional Biomarkers of Bone Mass in Early Childhood.

Karen M O'Callaghan, Celine Funk, Farzana Fariha, Marium H Nagaria, Alison Dasiewicz, Jennifer Harrington, Abdullah Al Mahmud, Steven A Abrams, Tahmeed Ahmed, Daniel R Moore and 1 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03537443 (Effect of Maternal Vitamin D Supplementation During Pregnancy on Offspring Bone Mass, Body Composition and Muscle Strength in Early Childhood), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03537443 nacompletednot on this map

Effect of Maternal Vitamin D Supplementation During Pregnancy on Offspring Bone Mass, Body Composition and Muscle Strength in Early Childhood: Follow-up of a Randomized Controlled Trial Cohort.

TypeinterventionalSponsorThe Hospital for Sick ChildrenRan2018 to 2020Enrolled642ConditionsSkeletal DisorderArmsCholecalciferol (vitamin D3)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Karen M O'CallaghanDepartment of Nutritional Sciences, King's College London, London, United Kingdom. Electronic address: karen.ocallaghan@kcl.ac.uk.
Celine FunkCentre for Global Child Health and SickKids Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
Farzana FarihaInfectious Disease Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Marium H NagariaCentre for Global Child Health and SickKids Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
Alison DasiewiczCentre for Global Child Health and SickKids Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
Jennifer HarringtonDepartment of Pediatrics, Women's and Children's Health Network, University of Adelaide, Adelaide, Australia.
Abdullah Al MahmudNutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Steven A AbramsDepartment of Pediatrics, Dell Medical School at the University of Texas at Austin, Austin, TX, United States.
Tahmeed AhmedNutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Daniel R MooreFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada.
Daniel E RothCentre for Global Child Health and SickKids Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe 25-hydroxyvitamin D (25(OH)D) concentration at which parathyroid hormone (PTH) concentration plateaus has been considered to benchmark vitamin D deficiency. However, in young children, there is limited evidence for a suppression point in the 25(OH)D-PTH relationship or its relevance to bone mass accrual.

objectivesTo determine whether the threshold of 25(OH)D at PTH suppression in young children is corroborated by associations of 25(OH)D (or PTH) with bone mineral content (BMC) and areal bone mineral density (aBMD).

methodsIn a cross-sectional secondary analysis of data from the BONe and mUScle health in Kids (BONUSKids) study of 4-y-old children in Bangladesh, serum 25(OH)D and intact PTH (iPTH) were analyzed by liquid chromatography-tandem mass spectrometry and a chemiluminescent immunoassay, respectively. BMC and aBMD were measured by dual-energy X-ray absorptiometry. Associations between 25(OH)D, iPTH, and bone outcomes (BMC, BMC z-score, aBMD, and aBMD z-score) were modeled using multivariable-adjusted linear regression and spline models. Model fit was compared using Akaike's Information Criteria.

resultsOf 534 participants (51% female), 28% had 25(OH)D concentrations <25 nmol/L and 34% had iPTH >6.7 pmol/L. Model fit of the inverse relationship between 25(OH)D and iPTH was optimized with an inflection point at 25 nmol/L [<25 nmol/L: -0.16 pmol/L per 1 nmol/L increase in 25(OH)D; 95% confidence interval (CI): -0.22, -0.10; P < 0.001), above which the slope attenuated (≥25 nmol/L: -0.02 pmol/L; 95% CI: -0.04, -0.003; P = 0.019]. However, the positive linear associations between 25(OH)D and bone mass outcomes were monotonic (P < 0.05), and iPTH was not associated with any bone outcome in adjusted models (P > 0.05 for all). Associations were similar in males and females.

conclusionsAmong 4-y-old children in Dhaka, Bangladesh, we did not identify a 25(OH)D threshold to define vitamin D deficiency based on its association with bone mass. However, efforts to raise 25(OH)D to ≥25 nmol/L may be warranted based on the relatively strong inverse association of 25(OH)D with iPTH below this threshold. This trial was registered at clinicaltrials.gov as #NCT03537443.

Indexed as

Bone and BonesBone DensityParathyroid HormoneVitamin DAbsorptiometry, PhotonBangladeshBiomarkersChild, PreschoolCross-Sectional StudiesFemaleHumansMaleVitamin D Deficiency25-hydroxyvitamin DBiomarkersParathyroid HormoneVitamin D25-hydroxyvitamin DBangladeshbone mineral contentbone mineral densitychildlow- and middle-income countriesparathyroid hormonevitamin D

Identifiers

PMID40139482
PMCPMC12264547

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.